linkedin post 2018-08-20 05:01:31

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JUNK DNA, REPEATS, TRANSPOSONS AND VIRAL ELEMENTS. “Over evolutionary time, viruses actively exchange genetic material with their host cells. However, just because a non-coding RNA expressed by a virus exhibits hallmarks of a known class of host cell non-coding RNAs does not mean that it necessarily functions comparably. Viruses are extremely clever at altering the bits of host cell genome that they acquire to meet their own needs.” https://lnkd.in/dD7FjZ4 View in LinkedIn
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linkedin post 2018-08-20 05:03:38

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“AT THE INTERSECTION of non-coding transcription, DNA repair, chromatin structure, and cellular senescence. Recent paradigm-setting studies are now revealing that non-coding RNAs, other than microRNAs, also play intriguing roles in the maintenance of chromatin structure, in the DNA damage response, and in adult human stem cell aging.” http://journal.frontiersin.org/article/10.3389/fgene.2013.00136/full View in LinkedIn
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linkedin post 2018-08-20 05:06:28

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EARLY PREDICTION. “The notion that repetitive copies of functional genes might govern, or trigger, the aging process had been suggested earlier by Medvedev. It was not until recently, however, that Olovnikov's remarkably insightful speculation was proven to be correct experimentally.” http://protein.bio.msu.ru/biokhimiya/contents/v62/full/62111380.html View in LinkedIn
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linkedin post 2018-08-20 05:07:50

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LIFESPAN AND GENOMES. “Although numerous different pathways for aging have been proposed, it is striking that human premature aging syndromes are caused by defects in the maintenance of genomic stability, indicating that genomic integrity plays a key role in determining lifespan.” https://lnkd.in/dKvxxVz View in LinkedIn
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linkedin post 2018-08-20 05:10:28

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DAMAGE CONTROL. “Genomic stability is closely intertwined with the chromatin structure. The chromatin structure not only regulates the accessibility of DNA damaging agents to the genome, but also plays critical roles in the signaling of DNA lesions and their repair.” http://journal.frontiersin.org/article/10.3389/fgene.2013.00136/full View in LinkedIn
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linkedin post 2018-08-21 04:40:53

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CHROMATIN. “Given the critical role of chromatin in regulating genomic stability and gene expression, it is tempting to speculate that some of the changes in gene expression and genomic integrity that occur during aging may be caused by the global changes to the chromatin structure that accompany aging.” http://journal.frontiersin.org/article/10.3389/fgene.2013.00136/full View in LinkedIn
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linkedin post 2018-08-21 04:44:10

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DNA DAMAGE RESPONSE. “Several different types of non-coding RNAs have been implicated in the DNA damage response. For example, many microRNAs (miRNAs) regulate genes that are involved in the DNA damage response." http://journal.frontiersin.org/article/10.3389/fgene.2013.00136/full View in LinkedIn
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