21Sep 2022 by Nigel Fleming No Comments

linkedin post 2019-11-09 06:15:31

Uncategorized
REPLICATION. “Viruses are genetic material encased in protein. They self-replicate and cause disease. Prions are just proteins. They self-replicate and cause disease. How viruses and prions work. Self-replication by hijacking or inducing mis-folding, respectively, might not be what biologists have in mind for self-replication, but the end result is still more virus particles and prions in the world.” https://lnkd.in/dzZgRcM View in LinkedIn
Read More
21Sep 2022 by Nigel Fleming No Comments

linkedin post 2019-11-10 05:14:03

Uncategorized
MUTANT SWARM. “According to the “cloud” hypothesis, pools of infectious isoform of prion protein (PrPSc) within individual strains or isolates are intrinsically heterogeneous; the heterogeneity presumably arises due to spontaneous variation in PrPSc structure. Upon changes in the replication environment, minor variants that fit best to replicate in the new environment receive selective advantages.” https://lnkd.in/dd6Nm4B View in LinkedIn
Read More
21Sep 2022 by Nigel Fleming No Comments
linkedin post 2019-11-10 05:16:29

linkedin post 2019-11-10 05:16:29

Uncategorized
HIGHLY ADAPTABLE. “Upon changes in the replication environment, minor variants that fit best to replicate in the new environment receive selective advantages. Consistent with this view, a growing number of studies have highlighted the fact that prion strains exhibit high levels of conformational plasticity and are subject to transformation when exposed to new replication environments.” http://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1003759 View in LinkedIn
Read More
21Sep 2022 by Nigel Fleming No Comments

linkedin post 2019-11-10 05:18:35

Uncategorized
FAMOUS DISCOVERY. “In the 1950s an epidemic transmissible disease called kuru, similar to CJD, was identified in the Fore tribe of Papua New Guinea. Transmission of the disease occurred during a ritual funeral process in which the brain of a dead tribe member was removed from the skull, cooked and eaten.” https://lnkd.in/dkdVKcb View in LinkedIn
Read More
21Sep 2022 by Nigel Fleming No Comments

linkedin post 2019-11-10 05:20:36

Uncategorized
LATENCY. “The latest research suggests that the infected meat may pose a threat to human health, but the significance of that threat may not become apparent for years. Although it is generally considered a British problem, BSE is almost certainly a natural disease of cattle, so it is undoubtedly found in other countries as well.” https://lnkd.in/dkdVKcb View in LinkedIn
Read More
21Sep 2022 by Nigel Fleming No Comments

linkedin post 2019-11-10 05:22:23

Uncategorized
INFECTIOUS AND HEREDITABLE. “Confusingly, researchers also recognized that some prion diseases, such as GSS, were inherited. The pattern of inheritance was recognized as being autosomal and dominant, meaning that if a parent developed GSS, there was a 50 percent chance that a child of either sex would also develop the disease.” https://lnkd.in/dkdVKcb View in LinkedIn
Read More