Month: September 2022

WHY IS THE UNNATURAL AMINO ACID IN BRAIN? "What about the metabolism of d-serine made in the brain? Here, the d-serine is produced mainly or exclusively in the cytosolic matrix of astroglia, which occur in close vicinity to NMDA receptors in the synapse-rich grey matter." https://lnkd.in/etGHsGm View in LinkedIn

D-ENZYMES. "When Sir Hans Krebs accidentally discovered an enzyme from kidney that recognized ‘non-natural’ D-amino acids (but not their L-counterparts), it was not clear why nature would have created such an enzyme." https://lnkd.in/etGHsGm View in LinkedIn

FRAGMENT IN NATURE this weekend is focused on a radical new opportunity in medicine that has the potential to rock the boat. Fecal transplants to restore unbalanced gut microbiota are being performed worldwide in an experimental basis. This fits with personalized medicine, and with the trend towards cellular therapies (stem cells, phage therapy). It is a (revived) outcome of the Human Microbiome Project. View in LinkedIn

OBESITY BIOME NOT DIVERSE. "The gut microbiota of obese humans are less diverse than their lean twins, consistent with the hypothesis that lower diversity may affect eating behavior and satiety." https://lnkd.in/eknVNSM View in LinkedIn

FECAL BIOTHERAPY. "A fecal microbiota transplant (FMT), also known as a stool transplant, is the process of transplantation of fecal bacteria from a healthy individual into a recipient. FMT involves restoration of the colonic microflora by introducing healthy bacterial flora." https://lnkd.in/e4DWYcp View in LinkedIn

"FMT has been used experimentally to treat clostridium difficile infection...colitis, constipation, irritable bowel syndrome, and neurological conditions such as multiple sclerosis and Parkinson's." https://lnkd.in/e4DWYcp View in LinkedIn

FMT: "In the United States, the FDA has regulated human feces as an experimental drug since 2013. It has potential to treat obesity, metabolic syndrome, diabetes, and autoimmune conditions." https://lnkd.in/e4DWYcp View in LinkedIn

PROBIOTIC WEIGHT LOSS. Probiotics are associated with weight loss in mice and humans. "Probiotic Bifidobacteria breve inhibited weight gain in mice given a high fat diet in a dose-dependent manner." https://lnkd.in/eknVNSM View in LinkedIn

POO THERAPY. "The practice of transfaunation has been used for centuries to treat ruminants with severe ruminal acidosis and other gastrointestinal disorders and for the treatment of equine diarrhea." https://lnkd.in/erygCxw View in LinkedIn

ANCIENT ORIGINS. "The concept of treating fecal diseases with fecal matter originated in China millennia ago. Fourth century Chinese medical literature mentions it to treat food poisoning and severe diarrhea." https://lnkd.in/e4DWYcp View in LinkedIn