Month: September 2022

SELECTIVE ADVANTAGE. "The presence of DAO enzymes in single-celled creatures allows them to grow on d-amino acid substrates, via the oxidation to achiral products. The selective advantage of being able to metabolize the d-amino acids made in bacteria has probably directed the evolution DAOs in animals." https://lnkd.in/etGHsGm View in LinkedIn

GABA RECEPTOR DISEASES. "Over the past 15 years, substantial evidence has accumulated to suggest that schizophrenia is somehow linked to a hypofunction in the glutamatergic neuro-transmitter systems in forebrain and limbic areas." https://lnkd.in/etGHsGm View in LinkedIn

THE "WRONG" AMINO ACIDS. "Bacteria do not produce d-serine in large quantities, but rather produce d-alanine, d-proline and d-glutamate for their cell walls. Eukaryotes, perhaps to eliminate the d-amino acids common in the prokaryotes they ingest and harbour, evolved DAO activities by elaborating on the structure of other flavin-requiring oxidases." https://lnkd.in/etGHsGm View in LinkedIn

BIOTECH UTILITY. "Recently, the extraordinary functional plasticity of DAO has become evident; in turn, boosting research in this flavoprotein. Protein engineering has allowed for a redesign of DAO substrate specificity, oxygen affinity, cofactors binding, stability, and oligomeric state." https://lnkd.in/e6tbA9E View in LinkedIn

"DAO DEFICIENCY is an alteration in the metabolism of food histamine that appears when Diamine Oxidase (DAO) enzyme activity is low, in other words, when for some reason there is a significant deficiency in the functional activity of the main enzyme in the metabolism of histamine. https://lnkd.in/e7VaYYg View in LinkedIn

DAO AND HISTAMINE. "The imbalance between ingested histamine and the histamine released from the histamine storage cells, and the capacity for histamine degradation, leads to histamine accumulation in plasma and the occurrence of adverse effects on health." https://lnkd.in/e7VaYYg View in LinkedIn

DAO DEFICIENCY TESTS. The test for DAO in serum (the histamine intolerance test), is useful in cases of suspected DAO deficiency. This can be combined with histamine analysis in blood, and a genetic test to see if it is primary DAO decency, or secondary to various drugs, inflammatory bowel disease or copper deficiency. A complete analysis. https://lnkd.in/e7SB5Wi View in LinkedIn

HIGH HISTAMINE TRIGGER FOODS. Fermented foods (cheese, yogurt and buttermilk; processed fermented meats (pepperoni, salami, bologna); fermented vegetables (sauerkraut); Fermented drinks (beer, ale and wine); Some fruits such as tomatoes and cherries, and citrus fruits. https://lnkd.in/eqsvvPT View in LinkedIn

DAO DEFICIENCY. "In healthy people, histamine taken with food is degraded quickly by Diamine Oxidase (DAO) enzyme, but people with low functional DAO activity have the risk of suffering histamine intolerance or food histaminosis." https://lnkd.in/e7VaYYg View in LinkedIn

QUIXOTIC. "Unlike food allergy, the occurrence of symptoms or adverse effects is not linked to the intake of specific food; not only can it be related to a wide variety of food with different histamine contents, symptoms can also occur even after the ingestion of products with low histamine levels." https://lnkd.in/e7VaYYg View in LinkedIn