Month: September 2022

ECOSYSTEM DYSBALANCE. "This promotes the increased translocation of pathogenic bacterial components from the intestinal mucosa to the systemic circulation, where they activate innate immunity, characterized by production of proinflammatory cytokines, resulting in systemic inflammation and abnormal gut function. These mechanisms potentially lead to impaired CNS function such as altered neurochemistry, cognition, behavior, stress response, and visceral pain." https://lnkd.in/egTKHRg View in LinkedIn

PSYCHIATRIC DYSBIOSIS. "Leaky gut or impaired intestinal permeability has been linked not only to the GI dysfunction but also to psychiatric disorders, such as depression and chronic fatigue syndrome. Microbial-based strategies that enhance barrier function may be useful for such disorders." https://lnkd.in/egTKHRg View in LinkedIn

PROBIOTIC REVERSAL. "In preclinical studies, administration of probiotics such as Lactobacillus farciminis, Bacteroides fragilis, and Lactobacillus salivarius can reverse the leakiness induced by acute stress, maternal infection, and hydrogen peroxide." https://lnkd.in/egTKHRg View in LinkedIn

PRENATAL INFECTIONS. "Epidemiological studies have indicated an association between common neurodevelopmental disorders, such as autism and schizophrenia, and microbial pathogen infections during the perinatal period. These findings are supported by experimental studies in rodents, demonstrating that exposure to microbial pathogens during similar developmental periods result in behavioral abnormalities, including anxiety-like behavior and impaired cognitive function." https://lnkd.in/e7Pmtsp View in LinkedIn

"PROBIOTICS (i.e., live microorganisms similar to beneficial microorganisms found in the human gut) are reported to modulate a number of disorders including metabolic disorders, behavioral conditions and cognitive functions." https://lnkd.in/eHd-EHP View in LinkedIn

FECAL TRANSPLANT THERAPY (available now as a pill). "Founded in 2012 by a team of microbiologists, clinicians, and public health advocates from Harvard and MIT, OpenBiome has since provided over 7000 treatments to more than 450 clinical partners across six countries, and has supported 10 clinical and translational research studies." https://lnkd.in/ecDqTkN View in LinkedIn

HACKING THE MICROBIOME. "And now evidence is emerging that these tiny organisms may also have a profound impact on the brain too. They are a living augmentation of your body – and like any enhancement, this means they could, in principle, be upgraded. So, could you hack your microbiome to make yourself healthier, happier, and smarter too?" https://lnkd.in/eq7NBt2 View in LinkedIn

SO ENDS this section showing in the last two weekends how parasites can influence the behavior of its host to the point of suicide; so it should come of little surprise that our resident commensalism symbiotic microbes living in our gut, which form our "second brain" can also have profound influences in our mood, mental health and physical health. We are entering a new phase of medicine: collaboration rather than adversity with nature. View in LinkedIn

ANCIENT VIRAL BITS AND PIECES. "By far the dominant type of nongenic DNA are transposable elements (TEs), including various well-described retroelements such as Short and Long Interspersed Nuclear Elements (SINEs and LINEs), endogenous retroviruses, and cut-and-paste DNA transposons." http://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1004351 View in LinkedIn

FECUND VIRAL FRAGMENTS. "Because of their capacity to increase in copy number, transposable elements have long been described as “parasitic” or “selfish”." https://lnkd.in/eT5V5Xc View in LinkedIn