Year: 2022

DATABASE. “Because genetic logic gates are the basic building biobricks of electronic circuits we developed a synthetic biology database of experimentally validated logic gates (SynBioLGDB) to facilitate related research.” https://www.nature.com/articles/srep08090 View in LinkedIn

BIOBRICKS. “This database is aimed at gathering a comprehensive collection of experimentally validated logic gates by manually curating the literature (Figure 1).” https://www.nature.com/articles/srep08090 View in LinkedIn

DATABASE STATUS. “The current version of SynBioLGDB documents more than 180 logic gates across three species (Human, Escherichia coli and Bacillus clausii).” https://www.nature.com/articles/srep08090 View in LinkedIn

CURATED. “SynBioLGDB therefore provides a global view of genetic logic gates in synthetic biology.” https://www.nature.com/articles/srep08090 View in LinkedIn

RESOURCE. “Researchers can follow these genetic logic gates to explore how the input and output of genes, proteins and promoters are organized.” https://www.nature.com/articles/srep08090 View in LinkedIn

SMART BEES. “Circumstances having given to the Bee its instinct is not more less wonderful than man his intellect.” (Charles Darwin, entry 115). https://lnkd.in/dbcVupKz View in LinkedIn

“PERSIMFANS was a conductorless orchestra in Moscow in the Soviet Union that was founded by Lev Tseitlin and existed between 1922 and 1932. Its name is an abbreviation for Pervïy Simfonicheskiy Ansambl' bez Dirizhyora (First Conductorless Symphony Ensemble).” Many biological analogies. https://lnkd.in/duSHh44y View in LinkedIn

INTERACTIVE. “The whole data set can be easily queried and downloaded from the website. In addition, SynBioLGDB allows researchers to submit new logic gates.” https://www.nature.com/articles/srep08090 View in LinkedIn

THE AND GATE. “Modular and orthogonal genetic logic gates are essential for building robust biologically based digital devices to customize cell signalling in synthetic biology. Here we constructed an orthogonal AND gate in Escherichia coli using a novel hetero-regulation module from Pseudomonas syringae.” https://lnkd.in/dsEUY4ZP View in LinkedIn

GENE GATE. “The device comprises two co-activating genes hrpR and hrpS controlled by separate promoter inputs, and a σ54-dependent hrpL promoter driving the output. The hrpL promoter is activated only when both genes are expressed, generating digital-like AND integration behaviour.” https://www.nature.com/articles/ncomms1516 View in LinkedIn