Year: 2022

MICRO-RNA. "Recent evidence supports the significant contribution of sRNAs and RNAi to the communication between hosts and some eukaryotic pathogens, pests, parasites, or symbiotic microorganisms. Mobile silencing signals — most likely sRNAs — are capable of translocating from the host to its interacting organism, and vice versa." (sRNA = microRNA; RNAi = RNA interference). https://lnkd.in/eFt2nSy View in LinkedIn

PATHOGEN MICRO-RNA EFFECTORS. "Recent evidence has also demonstrated the important roles of pathogen-derived sRNAs in host–microbe interaction. This is the first report of pathogen sRNAs acting as effectors to inhibit host immunity." https://lnkd.in/evpzgrd View in LinkedIn

PATHOGEN HIJACKING HOST. "In total, more than 70 Bc-sRNAs have been identified to be potential effectors based on plant expression and target gene prediction in both Arabidopsis and tomato hosts, for which three sRNA effectors have been demonstrated experimentally to silence host plant immunity genes by hijacking host RNAi machinery." (sRNA = small/microRNA). https://lnkd.in/evpzgrd View in LinkedIn

JUMPING GENES AND MICRO-RNA. "Long-Terminal Repeat (LTR) Retrotransposons Produce Masses of sRNAs That Provide a Large Selective Pool of sRNA Regulators for Pathogenicity." (sRNA = small/microRNA). https://lnkd.in/evpzgrd View in LinkedIn

BIDIRECTIONAL TRAFFICKING. "Trafficking sRNAs derive from various species, including plants, viruses, and fungi. In most cases, crossover by these RNAs occurs in host-parasites interactions. Unlike miRNAs transferred from plants to mammals, these interactions are not one-sided, but bidirectional." (sRNA = small/microRNA (miRNA)). https://lnkd.in/eqwgs-g View in LinkedIn

CROSS-KINGDOM. "There has been a report that microRNAs from food may regulate gene expression in mammals. It was shown that miR-168a from rice is transported from the gastrointestinal tract to target organs in mice. Another recent study published by the same group suggests that in influenza-infected mice honeysuckle exhibits its anti-viral potency via microRNA-2911. Yet, a so-called cross-kingdom regulation by microRNAs is still under debate." https://lnkd.in/erkHGt5 View in LinkedIn

"HERBAL MEDICINE has been used for thousands of years, however little is known about its molecular mechanism of action. Since the discovery of plant miRNA in human tissue and sera after ingestion, the connection between the two kingdoms is presented under a new perspective." http://www.sciencedirect.com/science/article/pii/S0753332215002012 View in LinkedIn

VIRAL ACTIVITY. "Our results demonstrate that MIR2911 is the first active component identified in Traditional Chinese Medicine to directly target various IAVs and may represent a novel type of natural product that effectively suppresses viral infection." (IAVs = Influenza A viruses) https://lnkd.in/exApn_B View in LinkedIn

HERBAL GENE REGULATION. "Moringa oleifera is a widespread plant with substantial nutritional and medicinal value. We postulated that microRNAs (miRNAs), which are endogenous, noncoding small RNAs regulating gene expression at the post-transcriptional level, might contribute to the medicinal properties of plants of this species after ingestion into human body, regulating human gene expression." https://lnkd.in/eBr8GUp View in LinkedIn

FRAGMENT FROM NATURE this next two weekends deals with parallel or convergent evolution, where two traits appear independently. Given the individual complexity and significant differences in molecular and structural organization, this fact seems at best improbable. The chance of being hit twice by lightning approaches the likelihood of such events, but read on, as they are simply not that rare. View in LinkedIn