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MOSTLY NEGATIVE. "Although TEs may occasionally play an adaptive role in their host's genome, they are much more often deleterious, and purifying selection is thus an important factor controlling genomic TE loads." (TE = transposable elements). https://lnkd.in/drMDPh6 View in LinkedIn

BIG SURPRISE. "This implies that the genetic and environmental backgrounds have remained relatively constant or have appeared repeatedly throughout evolution to allow for genetic loci to generate similar phenotypic changes in various taxonomic groups. This important finding was quite unsuspected some 50 years ago." https://lnkd.in/d3vzXnd View in LinkedIn

RICH SOURCE OF VARIATION. "Transposable elements (TEs) are a major source of genome variation across the branches of life." https://lnkd.in/drMDPh6 View in LinkedIn

CRITICAL QUESTIONS. "These observations raise the two central questions of this thesis. First, why are TEs so common, and the genomes so large, in some species but not others? Second, what prevents TEs from completely taking over and causing genomes to fail to produce functional individual organisms?" (TE = transposable elements). https://tspace.library.utoronto.ca/handle/1807/70840 View in LinkedIn

FOSSIL GRIST FOR THE MILL. "Transposable elements (TEs) are abundant in mammalian genomes and appear to have contributed to the evolution of their hosts by providing novel regulatory or coding sequences." https://lnkd.in/dwuaM5f View in LinkedIn

COST ENDURED. "Transposable elements (TEs) are mobile genetic elements that can self-replicate and insert elsewhere in the genome. This movement often comes with a fitness cost and yet TEs are tremendously common. They contribute more than 80% to the largest plant genomes, but are much less abundant in the smallest plant genomes." https://lnkd.in/dhVd8s4 View in LinkedIn

STABLE FOSSILS. "Since newly inserted TEs rarely undergo deletion they are highly stable polymorphisms." (TE = transposable elements). https://mobilednajournal.biomedcentral.com/articles/10.1186/s13100-015-0052-6 View in LinkedIn

HEREDITABLE GENETIC FOSSILS. "If members of these active TE families transpose in the germline, they can create novel insertions that are capable of being inherited, thereby generating human-specific polymorphisms." (TE = transposable elements). https://lnkd.in/dUmVr_n View in LinkedIn

FUNCTIONAL GENETIC FOSSILS. "Nevertheless, there remain a few families of actively transposing human TEs; the active families of human TEs include Alu, L1 and SVA elements. All three of these active families of human TEs are retrotransposons that transpose via reverse transcription of an RNA intermediate." (TE = transposable elements). https://mobilednajournal.biomedcentral.com/articles/10.1186/s13100-015-0052-6 View in LinkedIn

FOSSIL GRAVEYARD. "Much of the human genome sequence, anywhere from ~50 to 70 % depending on estimates, is derived from transposable elements (TE). The vast majority of TE-derived sequences in the genome are remnants of ancient insertion events, which are no longer capable of transposition." https://lnkd.in/dUmVr_n View in LinkedIn