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WORTH THE PRICE. “It has been shown that TEs can spread within and among genomes even in the face of a selective cost to the host.” (TE = transposable elements). https://lnkd.in/dwuaM5f View in LinkedIn

DOMINANT PURIFYING SELECTION. "We show that purifying selection against TEs is the dominant force throughout the evolutionary history of Nematoda, as indicated by reconstructed ancestral TE loads, and that strong stochastic Ornstein-Uhlenbeck processes are the underlying models which best explain TE diversification among extant species." (TE = transposable elements). https://lnkd.in/drMDPh6 View in LinkedIn

“THE STAGGERING evolutionary success of TEs in eukaryotes is often attributed to their ability to out replicate the host genomes in which they reside, as opposed to any selective advantage that they might provide to their hosts.” (TE = transposable elements). https://lnkd.in/dwuaM5f View in LinkedIn

FAST-TRACK PREFERENCE. "A significant positive correlation was detected between the content of TEs and evolutionary rate of lincRNAs indicating that inserted TEs are preferentially fixed in fast-evolving lincRNA genes." (TE = transposable elements; LincRNA= long intergenic non-coding RNA). https://lnkd.in/dwuaM5f View in LinkedIn

PREDOMINANCE IN PARALLEL UNIVERSE. "The content of TES in lincRNA genes is substantially higher than that in protein-coding genes, especially in exons and promoter regions." (TE = transposable elements; LincRNA= long intergenic non-coding RNA). https://lnkd.in/dwuaM5f View in LinkedIn

GENESIS. "Higher frequencies of ancient TEs in promoters and exons compared to introns implies that many lincRNA genes emerged before the split of primates and rodents." (TE = transposable elements; LincRNA= long intergenic non-coding RNA). https://lnkd.in/dwuaM5f View in LinkedIn

DISTRIBUTION OF VIRAL FOSSILS. "Introns of lincRNA genes contain the highest percentage of TE-derived sequences (TES), followed by exons and then promoter regions although the density of TEs is not significantly different between exons and promoters." (TE = transposable elements; LincRNA= long intergenic non-coding RNA). https://lnkd.in/dwuaM5f View in LinkedIn

DIFFERENT RULES IN PARALLEL UNIVERSE. "The promoters of lincRNA appear to similarly enjoy greater plasticity and flexibility compared to the promoters of protein-coding genes." (LincRNA= long intergenic non-coding RNA). Meditate upon this. https://lnkd.in/dwuaM5f View in LinkedIn

TWO TRACK SYSTEM. “Viral-derived fossil genes, mostly non-functional, have contributed significantly to the vast universe of genes controlling non-coding RNAs, the parallel universe to the coding genes that have obsessed geneticists for decades. The parallel universe (noncoding) is virally-driven, fast evolving, more flexible, and may turn out to control many cellular functions.” https://lnkd.in/dwuaM5f View in LinkedIn

PARALLEL UNIVERSE. "Here, we demonstrate that TEs substantially contribute to the evolution of lincRNAs and their promoter regions." (TE = transposable elements; LincRNA= long intergenic non-coding RNA). https://lnkd.in/dwuaM5f View in LinkedIn