linkedin post 2017-06-23 03:55:58

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BIRTH OF NEW GENES. “It has been demonstrated that non-autonomous MULEs can capture ectopic genomic sequences, such as gene fragments, and transpose them into new genomic locations, thereby forming putative new gene structures.” (MULEs = Mutator-like transposable elements). http://genomebiology.biomedcentral.com/articles/10.1186/s13059-016-0954-8 View in LinkedIn
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linkedin post 2017-06-23 03:51:03

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“NEW GENES can be created through various mechanisms, such as whole-genome duplication, small-scale duplication, illegitimate recombination, horizontal gene transfer, gene fusion, de novo origination from non-coding DNA sequence, RNA mediated retrotransposition, and dispersion/origination through TEs.” (TE = transposable elements). https://lnkd.in/dPzCkty View in LinkedIn
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linkedin post 2017-06-23 03:46:04

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“MUTATORS are class II DNA transposable elements (TEs) and have propagated widely across both prokaryotic and eukaryotic genomes through a “cut-and-paste” mechanism. The Mutator system was first reported in maize and was later found in other plants, bacteria, fungi and protozoans. Mutator-like transposable elements (MULEs) are especially pervasive in higher plant genomes such as rice (Oryza sativa), in which more than 10,000 copies have been identified.” https://lnkd.in/dPzCkty View in LinkedIn
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linkedin post 2017-06-23 03:41:56

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REPURPOSED VIRAL FOSSILS. “These examples are likely to reflect a more general phenomenon of exaptation and/or domestication during lncRNA evolution whereby TES are employed as DNA-, RNA-, and protein-binding domain/motifs.” (lincRNA = long intergenic non-coding RNA). https://lnkd.in/dwuaM5f View in LinkedIn
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linkedin post 2017-06-24 05:19:05

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HUMAN VERSUS VIRUS. "We might like to think of ourselves as the most “highly evolved” species but, in terms of how many rounds of mutation and selection we’ve undergone, we are one of the least evolved species. Around 10 billion new viral particles can be produced every day in the body of a person infected with HIV. By contrast, the total human population on Earth was no more than a few million until a few thousand years ago." https://www.newscientist.com/article/dn13640-evolution-myths-evolution-produces-perfectly-adapted-creatures/ View in LinkedIn
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linkedin post 2017-06-24 05:15:37

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UNIT OF SELECTION. “A realization of recent years is that mutant swarms are not mere collections of mutants ranked by a mutation-selection balance that act independently of each other. Rather, very often the mutant ensemble acts as a unit of selection due to interactions among its members.” http://www.sciencedirect.com/science/article/pii/S0042682215001580 View in LinkedIn
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linkedin post 2017-06-24 05:12:42

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DRIVING FACTORS. “Formation of mutant spectra with an abundance of single point mutants (and gradually decreasing proportions of double, triple and multiple mutants) is a necessary consequence of the mutation rate-genome size relationship.” http://www.sciencedirect.com/science/article/pii/S0042682215001580 View in LinkedIn
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