Category: Uncategorized

"A FUNDAMENTAL TENET of classical mendelian genetics is that allelic information is stably inherited from one generation to the next, resulting in predictable segregation patterns of differing alleles." https://lnkd.in/dQPBBj4 View in LinkedIn

NON-MENDELIAN INHERITANCE. "Researchers have identified more than 5,000 genetically inherited human diseases and abnormalities. As we learn more about the inheritance patterns for these traits, it is becoming clear that at least some of the twelve exceptions to the simple Mendelian rules of inheritance described here are, in fact, relatively common. It would not be surprising if other "exceptions" were discovered in the future." https://lnkd.in/dU9C5cY View in LinkedIn

MENDELIAN EXCEPTIONS. "There are many situation where the progeny phenotypes do not match the Mendelian principles. The non-Mendelian inheritance pattern plays a role in several processes of diseases." https://lnkd.in/dNPTzz9 View in LinkedIn

ODDITY. "We're trying to discover patterns in what seems to be chaos," says Charles Fenster, evolutionary biologist at the University of Maryland. "This interesting example is a departure from the known laws, but my guess is that it doesn't explain the vast majority of how genes are transmitted from generation to generation - the reason why individuals resemble each other. That's really the key issue, why individuals that are relatives resemble each other. That's why people are interested in genetics in the first place." https://lnkd.in/dv6b49K View in LinkedIn

MENDEL'S MODEL REVISIONS have sought to include the exceptions to his laws of heritable traits. Textbooks are revised to add the exclusions to Mendel’s laws, but they are the tip of the iceberg. https://lnkd.in/dkzHk9U View in LinkedIn

IMPACT OF EPIGENETICS. "Do Lolle's findings, if they turn out to be true, overturn Mendel's laws of inheritance? Some researchers say probably not, but they acknowledge that there are likely many undiscovered phenomena in transmission genetics that don't operate on a large enough scale to warrant throwing out the old rulebook. "Epigenetics has already shaken Mendel's laws," https://lnkd.in/dv6b49K View in LinkedIn

MENDELIAN RULES HOLD TRUE. "There are at least 18,000 human traits controlled by genes that follow the basic Mendelian rules of inheritance." https://lnkd.in/dU9C5cY View in LinkedIn

FAVORED EXPLANATION. "The RNA cache, on the other hand, Lolle proposes, is tapped when plants are under stress and is perhaps more than a one-time, random event. It is maintained outside the normal genomic context, inherited, and copied back into the DNA. There is a strong precedent for this mechanism to reside in RNA action." http://www.the-scientist.com/?articles.view/articleNo/26000/title/Mendel-upended-/ View in LinkedIn

ENDURING BASIS. "The distribution of phenotypes expected for the population of offspring can be determined by using Mendel's laws if the genotypes of both the parents are known." A remarkable legacy of work done in a monastery garden 156 years ago. https://lnkd.in/dNPTzz9 View in LinkedIn

EXPLANATIONS REJECTED. "Lolle and her colleagues, however, rejected these explanations. For one, the frequency at which some of the phenomena that Chaudhury and Ray proposed might occur were too small to account for the 10% reversion frequency that she and Pruitt had observed. "In fairness, they don't have all the data available." http://www.the-scientist.com/?articles.view/articleNo/26000/title/Mendel-upended-/ View in LinkedIn