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“ZEBRA SHARK surprises scientists by giving birth without male.” http://www.cnn.com/2017/01/17/health/zebra-shark-reproduction/index.html View in LinkedIn

PARTHENOGENIC MAMMALIAN EMBRYOS. "Parthenogenetic haploid embryonic stem cells efficiently support mouse generation by oocyte injection. Mammalian haploid embryonic stem cells (haESCs) have been recently generated from parthenogenetic and androgenetic embryos. Both parthenogenetic haESCs (PG-haESCs) and androgenetic haESCs (AG-haESCs) can be used for cell-based reverse and forward genetic screens on a whole-genome scale." https://lnkd.in/gdkjfHz View in LinkedIn

HUMAN HAPLOIDS. "Generation of human haploid embryonic stem cells from parthenogenetic embryos obtained by microsurgical removal of male pronucleus." https://lnkd.in/gxKpzTq View in LinkedIn

HAPLOID HUMAN STEM CELLS. "Here we generated and analysed a collection of human parthenogenetic ES cell lines originating from haploid oocytes, leading to the successful isolation and maintenance of human ES cell lines with a normal haploid karyotype. Haploid human ES cells exhibited typical pluripotent stem cell characteristics, such as self-renewal capacity and a pluripotency-specific molecular signature." (ES = embryonic stem cells). https://lnkd.in/gQeEBUz View in LinkedIn

GAMETE MANIPULATION. "Diploidy is a fundamental genetic feature in mammals, in which haploid cells normally arise only as post-meiotic germ cells that serve to ensure a diploid genome upon fertilization. Gamete manipulation has yielded haploid embryonic stem (ES) cells from several mammalian species but haploid human ES cells have yet to be reported." https://lnkd.in/gQeEBUz View in LinkedIn

HYBRID HAPLOID TREES. "In this study, we investigated the induction of haploid plants in ‘Hirado Buntan’ pummlo (Citrus grandis) through in-situ gynogenesis by pollination with irradiated pollens of trifoliate orange (255, 325 and 500 Gy) and ‘Tongshui 72-1 Jincheng’ sweet orange (255, 395 and 500 Gy)." http://www.sciencedirect.com/science/article/pii/S0304423816302710 View in LinkedIn

BIOLOGICAL IMPROVEMENTS. "Homozygous genotypes have great potential in breeding and genomic researches in higher plants. Induction of parthenogenesis via pollination with gamma-irradiated pollens is an efficient method to obtain haploid plants that can overcome the biological limitations of fruit trees." https://lnkd.in/g8XbsX2 View in LinkedIn

DOUBLE MOTHER MAMMALS. "Given the successful establishment of parthenogenetic haploid embryonic stem cells in the mouse, rat and monkey, we expect that our approach can also be applied in other mammalian species to produce bimaternal animals." https://lnkd.in/gCT7Dcz View in LinkedIn

TERM CHIMAERAS. "Previous attempts to achieve development to term of aggregation chimaeras between parthenogenetic and fertilised embryos were apparently unsuccessful. We have introduced inner cell masses (ICMs) from diploid, parthenogenetic embryos into intact fertilised mouse blastocysts, and we report here the development of a chimaera to term." https://lnkd.in/gAXZaG6 View in LinkedIn

BIMATERNAL MAMMALS. "Birth of fertile bimaternal offspring following intracytoplasmic injection of parthenogenetic haploid embryonic stem cells. We thus establish a novel strategy of generating bimaternal mammals, which is valuable to uncover the function of genomic imprinting, and to improve assisted reproduction in diverse mammalian species." https://lnkd.in/gCT7Dcz View in LinkedIn