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VULNERABILITY. "Meiosis may be specifically vulnerable to transposable element activity for several reasons. These include (1) deficient synapsis and repair due to the reshuffling of meiotic machinery towards transposable element-induced double strand breaks, (2) ectopic recombination among transposable elements, (3) interference with synapsis due to transposable element transcriptional activity." https://lnkd.in/e2tp_G5 View in LinkedIn

ASEXUAL MUTANTS. "The question of how a mitotic asexual mutant can invade a sexual species is at the heart of the debate on the evolutionary maintenance of sex, as this is what is investigated in most theoretical models, and is the situation where the cost of sex is most evident." http://biorxiv.org/content/biorxiv/early/2016/04/28/050831.full.pdf View in LinkedIn

RESETTING RISKS. "Many epigenetic pathways repress the activity of transposable elements, and so resetting epigenetic marks exposes the genome to mobilisation of these elements, which may be particularly detrimental when producing gametes." http://biorxiv.org/content/biorxiv/early/2016/04/28/050831.full.pdf View in LinkedIn

SEXUAL REVERSAL. "Examples of meiosis-derived modes of asexual reproduction include chromosome doubling prior to meiosis (“endomitosis” or “pre-meiotic doubling”), fusion of two of the four products of a single meiosis (“automixis” in animals, “within-tetrad mating” in fungi), and suppression of one of the two meiotic divisions." http://biorxiv.org/content/biorxiv/early/2016/04/28/050831.full.pdf View in LinkedIn

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ESCAPING RESETTING. "There are exceptions, and some genes specifically escape an epigenetic 2n→n ‘meiotic resetting’, leading to transgenerational epigenetic inheritance." http://biorxiv.org/content/biorxiv/early/2016/04/28/050831.full.pdf View in LinkedIn

EPIGENETIC RESETS “ensures proper development, the acquisition of parent-specific imprints, and might allow for mechanisms limiting the maximal number of possible successive mitoses (“Hayflick limit”, reducing tumour development." http://biorxiv.org/content/biorxiv/early/2016/04/28/050831.full.pdf View in LinkedIn

TWO RESETS. "Metazoan development is under the control of many epigenetic changes (cytosine methylation and chromatin marks) that are irreversibly maintained throughout life and must be reset twice each generation (at the n→2n and 2n→n transitions)." http://biorxiv.org/content/biorxiv/early/2016/04/28/050831.full.pdf View in LinkedIn

EPIGENETIC RESETTING. "It has been suggested that a primary function of meiosis is to allow for epigenetic resetting in eukaryotes." http://biorxiv.org/content/biorxiv/early/2016/04/28/050831.full.pdf View in LinkedIn

TRANSITION. "Meiosis and syngamy represent critical transitions between haploid and diploid phases in each generation." http://biorxiv.org/content/biorxiv/early/2016/04/28/050831.full.pdf View in LinkedIn