Category: Uncategorized

CONCLUSION. "It is now becoming clear that natural selection acts on large portions of the noncoding genome." https://lnkd.in/dPT523x View in LinkedIn

ALTERNATIVE HYPOTHESIS, A BYPRODUCT. "We investigate an alternate hypothesis that has been suggested, but heretofore untested, which is that modularity evolves not because it conveys evolvability, but as a byproduct from selection to reduce connection costs in a network." https://lnkd.in/eX5AfaH View in LinkedIn

EVIDENCE #1+#2 "has led to many researchers to ask whether phenotypic diversity is mainly determined by changes in protein-coding sequences or in the noncoding regulatory sequences." https://lnkd.in/dPT523x View in LinkedIn

HYPOTHESIS: MODULARITY CONVEYS EVOLVABILITY. "The leading hypothesis is that modularity mainly emerges because of rapidly changing environments that have common subproblems, but different overall problems." https://lnkd.in/eX5AfaH View in LinkedIn

EVIDENCE #2: "the fact that a large proportion of the nonprotein-coding DNA of eukaryotic genomes is actually functional." https://lnkd.in/dPT523x View in LinkedIn

EVIDENCE #1. There is "high level of similarity between proteins (in number and function), from phenotypically very different organisms." https://lnkd.in/dPT523x View in LinkedIn

EVIDENCE of selection on protein-coding and non-protein coding sequences follow. View in LinkedIn

POSITIVE SELECTION. "It is generally accepted that positive selection (selection in favor of advantageous mutations) plays an important role in the origin of new phenotypes. In fact, the evidence of selection acting on protein-coding sequences has increased enormously in the last 20 years." https://lnkd.in/dPT523x View in LinkedIn

ADAPTIVE SIGNPOSTS. "The rapid accumulation of genome sequences and the development of powerful statistical methods, to detect signatures of adaptation, provide us an unprecedented opportunity to increase our understanding of functionally important genomic regions." https://lnkd.in/dPT523x View in LinkedIn

FOOTPRINTS OF SELECTION. "Natural selection leaves imprints on DNA, offering the opportunity to identify functionally important regions of the genome." https://lnkd.in/dPT523x View in LinkedIn