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EARTH time lapse from geostationary satellites. https://lnkd.in/dc4eEFP View in LinkedIn

PLANET EARTH changes by time lapse. When we see from afar, at different time scales, the world changes. https://lnkd.in/dkSFzJ6 View in LinkedIn

DATA ALONE IS INSUFFICIENT. “As genomics continues to expand and to mature by addressing nearly every imaginable biological question, it is increasingly clear that the primary analysis of the resulting data alone is no longer sufficient for extracting new biological insights.” https://bmcsystbiol.biomedcentral.com/articles/10.1186/1752-0509-8-S2-S1 View in LinkedIn

MORE SOLOS. “Although genomics and systems biology have started to reshape a multitude of areas in biology, new subfields evolve with ever more specialization. Ironically, we suspect that systems biology and genomics are in fact contributing to a new era of specialization by creating entire new subfields such as developmental systems biology or pharmacogenomics.” https://bmcsystbiol.biomedcentral.com/articles/10.1186/1752-0509-8-S2-S1 View in LinkedIn

TRANSCRIPTS ARE KEY. “As gene expression analysis continues the transition to high-throughput sequencing, transcripts rather than genes become the fundamental feature measured and will require the update of functional profiling methods to support transcript-level functional analyses of enrichment.” https://bmcsystbiol.biomedcentral.com/articles/10.1186/1752-0509-8-S2-S1 View in LinkedIn

ARBITRARY FUNCTIONAL ASSIGNMENTS. “The assignment of genes to functions is still a largely unfinished task and the boundaries of pathway definitions are arbitrary: one database might include a set of genes within a specific signaling pathway while another would split this into two separate pathways.” https://bmcsystbiol.biomedcentral.com/articles/10.1186/1752-0509-8-S2-S1 View in LinkedIn

GREAT UNKNOWN. “Nearly half the genes of higher eukaryotes are proteins of unknown function or non-coding genes that await functional characterization.” https://bmcsystbiol.biomedcentral.com/articles/10.1186/1752-0509-8-S2-S1 View in LinkedIn

FUNCTIONAL CHARACTERIZATION. “High throughput screening methods for protein-coding genes, or computational predictive approaches in the case of non-coding transcripts might help to speed up functional characterization but are still at their infancy and far from being generally applicable.” https://bmcsystbiol.biomedcentral.com/articles/10.1186/1752-0509-8-S2-S1 View in LinkedIn

MICROBIOME STUDIES. “While we are accumulating large metagenomic datasets and cataloguing bacterial genomes that make up the different parts of the human microbiome in normal and diseased individuals, it is still very difficult to connect the presence or change in frequency of specific bacterial species with the associated phenotypes.” https://bmcsystbiol.biomedcentral.com/articles/10.1186/1752-0509-8-S2-S1 View in LinkedIn

DRUGS AND GENES. “The new field of pharmacogenomics seeks to understand the interactions between drugs and individuals' genotype. For example about 14% of the population carry the *2 allele of the cytochrome P450 CYP2C19 that prevents the proper processing of the anti-clotting drug clopidogrel (Plavix) and thus renders the drug ineffective.” https://bmcsystbiol.biomedcentral.com/articles/10.1186/1752-0509-8-S2-S1 View in LinkedIn