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SELFISH BRAIN. "The presented model includes a newly discovered ‘principle of balance’ of how pairs of high and low-affinity receptors can originate setpoints in biological systems. In this ‘Selfish Brain Theory’, the neocortex and limbic system play a central role in the pathogenesis of diseases such as anorexia nervosa and obesity." View in LinkedIn

EITHER-OR. "Increased growth of one trait occurs at the expense of growth in other traits, without overall changes in the size of the animal, much as faster-growing cells (e.g., minute+ cells expressed in a minute− background) out-compete neighboring cells for space within a growing imaginal disc without affecting the final size of the disc." http://www.pnas.org/content/95/7/3685.full View in LinkedIn

NUTRIENT FUNNELING TO BRAIN. "The brain has two possibilities to ensure its energy supply: allocation or intake of nutrients. The term ‘allocation’ refers to the allocation of energy resources between the brain and the periphery." http://www.sciencedirect.com/science/article/pii/S0149763404000259 View in LinkedIn

THIRD REGULATION. "Herein we illustrate a third and intermediate level of size regulation, manifest as what appears to be competition among growing traits within late-stage larvae immediately prior to pupation. Superficially, at least, the mechanism of trait competition described herein is similar to the process of cell competition and compensatory growth that operates within compartments of individual imaginal discs." http://www.pnas.org/content/95/7/3685.full View in LinkedIn

BRAIN METABOLISM WINS. "Here we present a new paradigm for the regulation of energy supply within the organism. The brain gives priority to regulating its own adenosine triphosphate (ATP) concentration. In that postulate, the peripheral energy supply is only of secondary importance." https://lnkd.in/dFnjHSQ View in LinkedIn

EXTERNAL REGULATORS. "It is clear that these trait-autonomous processes are also regulated at a higher level. In insects, developmental hormones such as the ecdysteroids and JHs and external factors such as starvation and extreme temperatures are known to affect whole-animal growth and thus also the final sizes of traits." (JH = juvenile hormone). http://www.pnas.org/content/95/7/3685.full View in LinkedIn

LIMITED RESOURCES. "Consequently, the number and the life expectancy of a B-cell clone vary according to the presence or absence of competitor populations. This process of lymphocyte competition is likely controlled by a common need for resources that are in limited supply." http://onlinelibrary.wiley.com/doi/10.1111/j.0105-2896.2004.0095.x/full View in LinkedIn

LYMPHOCYTE COMPETITION. "In an immune system where the total number of cells is limited, cell survival is no longer a passive phenomenon but rather a continuous active process where each lymphocyte must compete with other lymphocytes to survive." http://onlinelibrary.wiley.com/doi/10.1111/j.0105-2896.2004.0095.x/full View in LinkedIn

LYMPHOCYTE DYNAMICS. "In adult mice, the number of B lymphocytes remains constant under homeostatic control, in spite of the fact that B cells are produced continuously in numbers that largely exceed the number required to replenish the peripheral pools. It follows that each newly formed lymphocyte can only persist if another lymphocyte dies." http://onlinelibrary.wiley.com/doi/10.1111/j.0105-2896.2004.0095.x/full View in LinkedIn

LYMPHOCYTE DYNAMICS. "In adult mice, the number of B lymphocytes remains constant under homeostatic control, in spite of the fact that B cells are produced continuously in numbers that largely exceed the number required to replenish the peripheral pools. It follows that each newly formed lymphocyte can only persist if another lymphocyte dies." https://lnkd.in/d-HttRV View in LinkedIn