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ARGUMENTATIVE POSITION. "There is a tenable argument that the germ plasm is not immortal because molecules at the end of a lineage of zygotes are not identical to those in the founding gametes." https://lnkd.in/esfPTAR View in LinkedIn

VIBRATING SIGNAL. “When the slime mold senses attractants, such as food, via specific binding to receptor molecules presented on the outer membrane surface, the oscillation frequency in the area closest to the food increases, causing cytoplasm to flow toward the attractant. Additionally, binding of attractant molecules to sections of the surface membrane reduces the tension at that section, leading to a difference in internal hydrostatic pressure, such that cytoplasm flows toward the source of attractants.” http://www.pnas.org/content/109/43/17490.full View in LinkedIn

ALL MOLECULES TURN OVER. "In 1891 August Weismann proposed that the germ plasm is immortal. Yet, the repeated replication and repair of DNA results in molecules that do not contain atoms of the same nucleotides present in the DNA of a founding cell." (L. Haflick, the brilliant contrarian, adopting an overly rigid definition of immortality). https://lnkd.in/esfPTAR View in LinkedIn

OSCILLATING UNITS. “The slime mold Physarum polycephalum is a unicellular, multinucleate protist that relies on reactive navigation to explore its environment. The vegetative state of P. polycephalum (known as a plasmodium) is composed of many smaller oscillating units. Each unit oscillates at a frequency dependent upon both the local environment and its interactions with neighboring oscillators.” https://lnkd.in/gxeWCUg View in LinkedIn

THE WHY. "The puzzle has two sides: why and how has the somatic part of higher animals come to be mortal, and how is the germ-line kept free of the progressive deterioration in the soma?" http://link.springer.com/chapter/10.1007/978-1-4613-1939-9_15 View in LinkedIn

ESSENTIAL. "In recent years, it has become consummately clear that changing of epigenetic modification is essential during both early and late oogenesis and spermatogenesis." https://lnkd.in/gCPVDZd View in LinkedIn

Routine DNA tests will put NHS at the 'forefront of medicine' https://www.theguardian.com/science/2018/jul/03/nhs-routine-dna-tests-precision-cancer-tumour-screening?CMP=Share_iOSApp_Other View in LinkedIn

TWO FATES. "Epigenetic information is frequently erased near the start of each new generation. In some cases, however, epigenetic information can be transmitted from parent to progeny (multigenerational epigenetic inheritance)." http://www.nature.com/nature/journal/v489/n7416/abs/nature11352.html View in LinkedIn

REPROGRAMMING. "It has long been suspected that epigenetic modifications could play a role in limiting the developmental potential of a tissue during the complex pattern of tissue differentiation. This has led to the idea that a fundamental aspect of the difference between the ‘‘mortal’’ soma and the ‘‘immortal’’ germline may be the ability to reprogram the genome of the germ cells epigenetically in order to maintain totipotency." View in LinkedIn

RESET BUTTON. "Epigenetic information undergoes extensive reprogramming in the germline between generations. During normal germline transmission, the epigenetic state of the genome is known to undergo reprogramming both in the gametes and the early embryo." https://lnkd.in/gt5vs8F View in LinkedIn