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SOMA AND GERM COLLABORATION. "Importantly, development of male and female gametes does not occur in isolation. The formation of meiocytes, gametophytes, and gametes requires the active presence of neighboring helper cells. Recent data on the interaction between reproductive cell lines and these largely somatic helper populations highlight not only the complexity of this relationship and the significance of the events it regulates but also its two-way nature." http://www.sciencedirect.com/science/article/pii/S1534580713000427 View in LinkedIn

LAND PLANT CHARACTERISTICS. #2. "Second, they develop multicellular, parenchymatous structures that produce eggs and sperm (called archegonia and antheridia, respectively)." http://onlinelibrary.wiley.com/doi/10.1111/j.1469-8137.2009.03054.x/full View in LinkedIn

"THE CUES that mediate the transition of the different stages of the life cycle are likely to involve epigenetic mechanisms." http://rstb.royalsocietypublishing.org/content/367/1588/508.short View in LinkedIn

LAND PLANT CHARACTERISTICS. #1. "The embryophytes are unique among all extant lineages in possessing three important and interrelated reproductive attributes. First, they possess a sexual life cycle that requires an alternation between a multicellular haploid generation, which produces sperm and egg cells (the gametophyte), and a multicellular diploid generation, which produces meiospores with sporopollenin-rich walls (the sporophyte)." https://lnkd.in/dcZcdNY View in LinkedIn

CONTROL SYSTEMS. "Evidence is accumulating that major gene-switching events in plants, such as flowering, are regulated by complex control systems which ensures that development occurs only in the correct groups of cells at the appropriate time. A similar, or more sophisticated system might thus be expected to regulate alternation of generation." http://onlinelibrary.wiley.com/doi/10.1111/j.1469-185X.1994.tb01277.x/abstract View in LinkedIn

DAMAGE. “The accumulation of DNA damage is a hallmark of aging and senescing cells, and the DNA damage signal emanating from shortened telomeres triggers cells to enter a state of senescence.” https://lnkd.in/dKvxxVz View in LinkedIn

LIFESPAN AND GENOMES. “Although numerous different pathways for aging have been proposed, it is striking that human premature aging syndromes are caused by defects in the maintenance of genomic stability, indicating that genomic integrity plays a key role in determining lifespan.” https://lnkd.in/dKvxxVz View in LinkedIn

EARLY PREDICTION. “The notion that repetitive copies of functional genes might govern, or trigger, the aging process had been suggested earlier by Medvedev. It was not until recently, however, that Olovnikov's remarkably insightful speculation was proven to be correct experimentally.” http://protein.bio.msu.ru/biokhimiya/contents/v62/full/62111380.html View in LinkedIn

REPEATS AND SENESCENCE. “Induction of non-coding RNA transcription from the repetitive Alu elements occurs during human stem cell aging and hinders efficient DNA repair causing entry into senescence.” http://journal.frontiersin.org/article/10.3389/fgene.2013.00136/full View in LinkedIn

“AT THE INTERSECTION of non-coding transcription, DNA repair, chromatin structure, and cellular senescence. Recent paradigm-setting studies are now revealing that non-coding RNAs, other than microRNAs, also play intriguing roles in the maintenance of chromatin structure, in the DNA damage response, and in adult human stem cell aging.” http://journal.frontiersin.org/article/10.3389/fgene.2013.00136/full View in LinkedIn