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REF FOR TODAY’S POST. Are Internal, Death-Promoting Mechanisms Ever Adaptive?" "John W Pepper, Deborah E Shelton, Armin Rashidi and Pierre M Durand" "Journal of Phylogenetics & Evolutionary Biology View in LinkedIn

DEPTH AND DEFINITIONS. "How far “down” the evolutionary ladder one can expect programmed cell death to exist depends on how one defines the phenomenon." https://lnkd.in/dVeZ2yE View in LinkedIn

INFLAMMASOMES. "Perhaps the best piece of evidence in favor of an origin of apoptosis in the context of host defense is the fact that apoptosis‐initiating complexes such as the apoptosome and immunity‐activating complexes such as the inflammasomes are very similar to each other." https://celldeath.files.wordpress.com/2010/11/lopezself_munoz.pdf View in LinkedIn

DEATH AS CARNAGE? "A significant fraction of the cells that are generated in C. elegans are subsequently eliminated by programmed cell death: about 12% during somatic development, even more in the germ line. Many a student of C. elegans, impressed by the efficiency and finesse of its development, has marveled at this apparent waste of energy." https://lnkd.in/dVeZ2yE View in LinkedIn

CHEATERS. "The origins of a suicidal program in single‐celled organisms are hard to understand, because the cells that acquired the ability to kill themselves would likely have a disadvantage and the emergence of “cheaters” with mutant genes would impair the maintenance of such a program. However, the emergence of such a process could be explained in the context of an infection." https://celldeath.files.wordpress.com/2010/11/lopezself_munoz.pdf View in LinkedIn

AUTOPHAGY. "Potential convergence on the autophagic death phenotype also indicates that death-promoting mechanisms may have been selected for in unicells. The autophagic death phenotype and elements of its molecular pathway have been described in evolutionarily diverse, unrelated unicellular eukaryotes such as the stramenopiles, the kinetoplastids and the social amoebae." View in LinkedIn

PROKARYOTIC DEATH GENES. "The caspase gene super-family is involved in cell death in both prokaryotes and eukaryotes, suggesting that it is functionally conserved and arose early in prokaryote evolution." View in LinkedIn

CONSERVED AND ADAPTED. "The ancient and deeply conserved genetic and molecular pathways that cause cell death indicate that death-promoting mechanisms show less variability than would be expected for unavoidable or maladaptive death.” View in LinkedIn

INTERNAL REAPER. "There is substantial evidence that cell death is often internally controlled and regulated in unicellular organisms." View in LinkedIn

PROGRAMMED CELL DEATH "seems paradoxical, however, in cases where the single cell is the entire organism. In some species ambiguity arises as to whether cells are organisms or parts of organisms." View in LinkedIn