linkedin post 2020-02-19 05:27:18
THE BRAIN IS IMMUNOLOGICALLY PRIVILEGED. The brain and testes do not reject foreign tissues. View in LinkedIn
linkedin post 2020-02-19 05:26:15
HUMAN BRAIN MAKES SMARTER MICE. "Goldman first reported last year that mice with human glial cells are smarter. But the human cells his team injected then were mature so they simply integrated into the mouse brain tissue and stayed put." https://lnkd.in/d2TkhaZ View in LinkedIn
linkedin post 2020-02-19 05:24:41
NEW HYBRID MODEL. "These human glial-chimeric mice may present a fundamentally new experimental model by which human glial cells, and both normative and pathological species-specific aspects of human glial biology, may now be effectively studied in the live adult brain." https://lnkd.in/dQ9_J77 View in LinkedIn
linkedin post 2020-02-19 05:21:37
HAN ET AL. "Forebrain engraftment by human glial progenitor cells enhances synaptic plasticity and learning in adult mice. Upon maturation, the recipient brains exhibited large numbers and high proportions of both human glial progenitors and astrocytes. Long term potentiation (LTP) was sharply enhanced in the human glial chimeric mice, as was their learning, as assessed by Barnes maze navigation, object-location memory, and both contextual and tone fear conditioning." https://lnkd.in/dQ9_J77 View in LinkedIn
linkedin post 2020-02-19 05:20:14
HUMAN-MOUSE BRAIN HYBRIDS. "We created human glial-chimeric mice, in which immunodeficient but otherwise normal mice were engrafted neonatally with large numbers of human glial progenitors, resulting in the widespread integration of human glia into the mouse brain." https://lnkd.in/dQ9_J77 View in LinkedIn
linkedin post 2020-02-19 05:17:37
BRAIN CELL TRANSPLANT. "In 2013, Xiaoning Han and colleagues in the laboratories of Steven Goldman and Maiken Nedergaard at the University of Rochester Medical Center published a paper examining the possibility of augmenting neural processing ability of one species by surgically transplanting cells from the brain of another “more advanced” species." https://lnkd.in/dAifP-w View in LinkedIn
linkedin post 2020-02-18 06:01:22
HUMAN-RAT CHIMERA. "Human neural precursors were then expanded 100-fold prior to intrastriatal transplantation in a rodent model of Parkinson's disease...given the relative safety profile for these human cells and their capacity to extend fibers into the adult rodent brain, they may provide the ideal basis for the repair of other lesions of the CNS." https://lnkd.in/ecGstiF View in LinkedIn
linkedin post 2020-02-20 05:46:06
HIT THE JACKPOT. "This is a profoundly surprising and unexpected finding...It is possible to replace mouse astrocytes with human astrocytes and not only get a live mouse, but [get] one that learns and remembers better than normal counterparts.” http://www.the-scientist.com/?articles.view/articleNo/43327/title/When-Does-a-Smart-Mouse-Become-Human-/ View in LinkedIn
linkedin post 2020-02-18 05:59:44
FLY-AMPHIBIAN HYBRID. "Cells of the neural primordia of the Notch mutant of Drosophila melanogaster are transplanted to the neural tube of four amphibian species and two mammalian species. It is shown that cells of the neural primordia of drosophila survive and differentiate in the amphibian and mammalian brain." https://lnkd.in/eTEWncR View in LinkedIn
linkedin post 2020-02-20 05:45:06
THE UNKNOWN. "Reconstituting human glial cells or neurons in animal brains could eventually impart complex cognitive behaviors, self-awareness, and/or other humanlike personality characteristics to these chimeras." https://lnkd.in/dTarAZs View in LinkedIn