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ROBUSTNESS LANDSCAPE. “Waddington envisaged this “epigenetic landscape” as being shaped by genes (pegs in the ground) which were connected to each other and the landscape by guide ropes that mold the valleys that constrain lineage fate.” https://lnkd.in/dfCi2dc View in LinkedIn

NETWORK ROBUSTNESS. “A key feature of networks is robustness, or resilience to genetic or environmental attack, or random fluctuations in gene expression. Robustness underlying development was captured by Conrad Hal Waddington’s visual metaphor of a ball rolling down a valley system in a terrestrial landscape.” https://lnkd.in/dfCi2dc View in LinkedIn

NIGHT LIGHT IMPACT. “Shift workers, who are exposed to high levels of light at night in the workplace, have served as society's canaries in the coal mine for maladaptive consequences of nighttime light exposure. Epidemiological evidence from shift workers suggests that prolonged exposure to light at night increases the risk of developing cancer, sleep disturbances, mood disorders, metabolic dysfunction, and cognitive impairments.” https://lnkd.in/dH6Ha79 View in LinkedIn

HEART OF THE BODY PLAN. “Deciphering the mechanisms that drive development is a long-standing challenge. Emphasis has been placed on revealing the “decision makers” that give rise to cellular identity and to mapping the signaling pathways that enable the reproducible construction of the body plan through successive generations.” https://lnkd.in/dfCi2dc View in LinkedIn

THE HEAVY TOUCH OF LIGHT. “Given the well-established role of light in modulating the circadian system, and the relationship between circadian and metabolic functions, it is not surprising that exposure to light at unnatural times affects metabolism. Exposure to continuous-light, non–24-hour light schedules, and dim light at night are all associated with metabolic changes in rodents.” https://lnkd.in/dH6Ha79 View in LinkedIn

OSCILLATING HORMONES. “Appropriate circadian regulation is important for many homeostatic functions including energy regulation. Multiple genes involved in nutrient metabolism display rhythmic oscillations, and metabolically related hormones such as glucagon, insulin, ghrelin, leptin, and corticosterone are released in a circadian fashion.” https://lnkd.in/dH6Ha79 View in LinkedIn

CIRCADIAN TRIGGERS. “The time of day at which dietary fat is eaten also influences multiple cardiometabolic parameters. High-fat meals eaten at the end, as compared with the beginning, of the dark phase lead to features of metabolic syndrome including weight gain, elevated adiposity, reductions in glucose processing, hyperinsulinemia, hyperleptinemia, and hypertriglyceridemia.” https://lnkd.in/dH6Ha79 View in LinkedIn

CLOCK ALTERATIONS. “In humans, metabolically related diseases such as obesity and anorexia nervosa are associated with altered hormone and body temperature rhythms. Obese individuals lack typical daily rhythms in glucose and insulin sensitivity. Moreover, obese women have significantly lower wrist temperature and a flattened temperature rhythm compared with normal-weight controls.” https://lnkd.in/dH6Ha79 View in LinkedIn

TWO WAY. “The relationship between the circadian system and metabolism appears to be bidirectional. In addition to circadian system disruptions causing obesity, metabolic abnormalities alter circadian rhythms.” https://lnkd.in/dH6Ha79 View in LinkedIn

Judit Anido Folgueira #Kudos #ThankYou very much for everything you do! We now have moved to Girona. Do visit. View in LinkedIn