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SUGGESTIVE DATA. “Here, we summarize major findings from recent research in this area (2013–2017). In general, nighttime administration of antihypertensives improved overall 24-h blood pressure profiles regardless of disease comorbidity. However, inconsistencies between studies suggest a need for more prospective randomized controlled trials with sufficient statistical power.” https://link.springer.com/article/10.1007/s11906-018-0897-4 View in LinkedIn

EFFECTIVE DOSING. “To more effectively reduce nocturnal blood pressure and still counteract the morning surge in blood pressure, a number of studies have examined moving one or more antihypertensives from morning to bedtime dosing.” https://link.springer.com/article/10.1007/s11906-018-0897-4 View in LinkedIn

BLOOD PRESSURE MEDS. “There is a well-documented 24-h pattern of blood pressure with a morning surge that may contribute to the observed morning increase in adverse cardiovascular events. Historically, antihypertensive therapy involves morning doses, usually aimed at reducing daytime blood pressure surges, but an absence of nocturnal dipping blood pressure is also associated with increased cardiovascular risk.” https://link.springer.com/article/10.1007/s11906-018-0897-4 View in LinkedIn

NEW POSSIBILITIES. “This suggests that chronotherapy, either in terms of external clock time or internal biological time, is underutilized and could be a major consideration to improve modern personalized medicine.” https://link.springer.com/article/10.1007/s11906-018-0897-4 View in LinkedIn