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MANY VARIABLES. “Expression alterations of clock genes are associated with key oncogenic pathways, patient survival, tumor stage, and subtype in multiple cancer types.” https://lnkd.in/dT2NKaY View in LinkedIn

LARGE CANCER STUDY. “We systematically characterized the alterations of clock genes across 32 cancer types by analyzing data from The Cancer Genome Atlas, Cancer Therapeutics Response Portal, and The Genomics of Drug Sensitivity in Cancer databases.’ https://lnkd.in/dT2NKaY View in LinkedIn

ONCOLOGY. “Cancer chronotherapy, treatment at specific times during circadian rhythms, endeavors to optimize anti-tumor effects and to lower toxicity. However, comprehensive characterization of clock genes and their clinical relevance in cancer is lacking.” https://lnkd.in/dT2NKaY View in LinkedIn

EXQUISITE REGULATORY INTERACTIONS. “Specification of organ territories or lineages during development requires a progressive restriction of options within cellular fields. This invariably involves a complex reciprocal molecular dialog between neighboring cells.” https://lnkd.in/dfCi2dc View in LinkedIn

SELECTOR GENES. “Others can only do this as part of a TF collective. Certain TFs, termed “pioneer factors,” can find their target sites even in closed chromatin and may “bookmark” these sites during mitosis. It is likely that selector proteins and kernel TFs, as well as proteins that can reprogram cell fate autonomously, have pioneer qualities.” (TF = transcription factors). https://lnkd.in/dfCi2dc View in LinkedIn

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NETWORKS OF SWITCHES. “In essence, selector genes are factors that are involved in switching functions within the GRN that impact on cell lineage or morphogenetic fate. Some of these may have the property ascribed to master regulators in being able to cell-autonomously affect a network switch.” (GRN = gene regulatory networks). https://lnkd.in/dfCi2dc View in LinkedIn

FAMOUS MASTER REGULATOR. “In some circumstances, selector genes may have the properties of master regulators—factors, such as the muscle-specific TF MyoD1, which alone can induce muscle fate when expression is induced in a variety of cell types.” (TF = transcription factors). https://lnkd.in/dfCi2dc View in LinkedIn

SELECTOR GENES. “In the contemporary view, selector genes are distinguished from other TFs because they play a deterministic role in “selecting” the overarching developmental program for germ layers, developmental fields, lineage compartments, individual metameric units, or cell types.” (TF = transcription factors). https://lnkd.in/dfCi2dc View in LinkedIn

GENE TRIGGERS. “Here, gain or loss of single-selector genes invoke a shift in the total program for creation of a morphological structure; for example, the stable transformation of a leg into an antenna through loss of the homeobox (Hox) gene Antennapedia.” https://lnkd.in/dfCi2dc View in LinkedIn