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CLINICALLY IMPORTANT GENES. “We identified interactions between clock genes and clinically actionable genes by analyzing co-expression, protein-protein interaction, and chromatin immunoprecipitation sequencing data and also found that clock gene expression is correlated to anti-cancer drug sensitivity in cancer cell lines.” https://lnkd.in/dT2NKaY View in LinkedIn

CLOCK GENES IN CANCER. “Correlations between expression of clock genes and of other genes in the genome were altered in cancerous versus normal tissues.” https://lnkd.in/dT2NKaY View in LinkedIn

GRID ANALYSIS. “Despite the arrhythmicity caused by double or triple knockdown, the interactive effects of these paralog genes in cancer remain unclear. Here, we compared pathway score in tumor samples with high expression of paralog clock genes in combination versus tumor samples with low expression of paralog clock genes in combination.” https://lnkd.in/dT2NKaY View in LinkedIn

TRANSLATIONAL MEDICINE AT ITS BEST. “Our results provide a systematic analysis of clock genes across different cancer types, and highlight the significant roles of circadian clock in cancer chronotherapy. Our results provide the global view of clock transcriptional loops in multiple cancer types. Our results showed that clock genes are highly associated with activation or inhibition of multiple oncogenic pathways.” https://lnkd.in/dT2NKaY View in LinkedIn

Graffiti. View in LinkedIn

MASSIVE CANCER STUDY. “In this study, we systematically analyzed genomic profiling and clinical data from The Cancer Genome Atlas (TCGA) (The Cancer Genome Atlas Research Network et al., 2013) as well as drug sensitivity data from the Cancer Therapeutics Response Portal (CTRP) (Rees et al., 2015) and Genomics of Drug Sensitivity in Cancer (GDSC).” https://lnkd.in/dT2NKaY View in LinkedIn

SO ENDS this two weekend section on animal genetic regulatory kernels, and the Dutch-doll hierarchical maze of control systems that underpin development and morphogenesis; layer ontop of this the drift of the system during evolution, and a three dimensional array of controls emerges. It is but one of many snapshots of how exquisitely nature is organized, especially in the light of the gradual cooling and decay of the universe which surrounds life. View in LinkedIn

CANCER AND CLOCK GENES. “Therefore, preventing disruption of the circadian rhythm has the potential to improve the efficacy of cancer therapy. On the other hand, circadian rhythms could be reprogrammed in tumors.” https://lnkd.in/dT2NKaY View in LinkedIn

CLOCK GENES AND TUMORS. “Despite the arrhythmicity caused by double or triple knockdown, the interactive effects of these paralog genes in cancer remain to be ascertained. On one hand, loss of circadian homeostasis increases the risk of tumorigenesis in multiple cancer types.” https://lnkd.in/dT2NKaY View in LinkedIn