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CLOCK GENE DYSFUNCTION. “We sought to systematically investigate the contributions of circadian rhythm disruption and impaired molecular clockworks to tumorigenesis. Several thousand genes lost their correlation to clock genes in tumor samples. We also found that correlation among core clock genes was reduced significantly.” https://lnkd.in/dT2NKaY View in LinkedIn

CELL LINE STUDIES. “To further investigate the potential effects of clock genes on drug sensitivity, we examined the correlation between transcriptional expression of clock genes in the Cancer Cell Line Encyclopedia dataset and drug sensitivity in the CTRP dataset.” https://lnkd.in/dT2NKaY View in LinkedIn

POWERFUL REGULATOR. “DNA methylation regulates gene expression in cancer. We examined the promoter DNA methylation patterns of clock genes across different cancer types and observed an overall negative correlation between DNA methylation and gene expression (Figure S3A). We further observed multiple small alterations with a few genes showing differentially methylated patterns.” https://lnkd.in/dT2NKaY View in LinkedIn

GENES AND MEDICINES. “For drugs with known targeted genes, we further estimated the correlations between targeted genes and clock genes.” https://lnkd.in/dT2NKaY View in LinkedIn

CLOCK GENES AND CANCER. “These results suggest that genetic alterations of clock genes play functional roles in cancer.” https://lnkd.in/dT2NKaY View in LinkedIn

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MUTATED CLOCK GENES. “To further determine genetic alterations of clock genes in human cancer, we analyzed non-silent mutations of clock genes across cancer types. We observed that mutation frequency is relatively low for core clock genes, with fewer than five mutations in the majority of samples (Figure 3B). However, mutations of core clock genes were associated with patients' overall survival.” https://lnkd.in/dT2NKaY View in LinkedIn

Ancient pentagon skewed by street constraints, not fully corrected by internal editing. View in LinkedIn

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DRUGS LINK TO GENES. “We identified 2,059 significant correlation pairs between drug sensitivity and transcriptional expression of clock genes (Figure S7B). Among these, sensitivity to 82 anti-cancer drugs significantly correlated with at least 10 clock genes.” https://lnkd.in/dT2NKaY View in LinkedIn