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Marly limestone in building materials in Girona, including the several types of silt inclusion colors, and larger coin shell fossils that are among the biological sources of the limestone itself. These fossils are a major topic by themselves. View in LinkedIn

TRANSITION TO A NEW TOPIC. This is now the end of the cancer chronobiology section, and chronobiology in general, and tomorrow we transition into a section that considers plants, specifically, how plants make decisions, and how they plan. While some have called this ‘plant intelligence’, the term itself has been ill-chosen, and caused a firestorm of controversy. But regardless, there is strong evidence that plants have sophisticated abilities to make decisions, as we shall see. View in LinkedIn

A TRUY REMARKABLE STUDY of chronobiology in cancer, from a collaboration involving a number of major labs and disciplines. This is a magnificent example of clinically applied basic research and supports the premise that basic research is critical for the advancement of useful knowledge. Translational medicine now has this study as a poster child of what is possible. https://lnkd.in/dT2NKaY View in LinkedIn

PRACTICAL IMPORTANCE. “Finally, we showed that the majority of clinically actionable genes strongly correlate and interact with clock genes, suggesting that the circadian timing should be considered in cancer therapy.” https://lnkd.in/dT2NKaY View in LinkedIn

NEW DIAGNOSTICS. “Clock genes showed significant difference for distinct patient subtypes within a cancer type, and may serve as promising biomarkers. Our results highlight the possible clinical utility of clock genes in human cancer.” https://lnkd.in/dT2NKaY View in LinkedIn

THE FUTURE OF ONCOLOGY. “Furthermore, we identified clock genes that have potential clinical relevance based on associations between the expression levels of clock genes and survival times, tumor stage, or subtype. Multiple clock genes are associated with patient survival and differentially expressed among tumor stages, suggesting potential alterations of clock genes during tumor progression.” https://lnkd.in/dT2NKaY View in LinkedIn

NEW TREATMENT AVENUES. “There is an urgent need to consider the disruption and/or reprogramming of circadian rhythm in cancer treatment.” https://lnkd.in/dT2NKaY View in LinkedIn

CIRCADIAN DISRUPTION IN CANCER. “Our study showed a global disruption of circadian rhythms in both patient samples and cancer cell lines. In cancer patients, number of genes correlated to clock genes is largely reduced, suggesting the disruption of circadian rhythm.” https://lnkd.in/dT2NKaY View in LinkedIn

Marly limestone, common around Vic in Catalonia. An example of the unsolved material complexity mixed with archaic terms in geology. View in LinkedIn

MULTILEVEL STUDY. “Our comprehensive analysis of clock genes at the transcriptional, genetic, and epigenetic level is the crucial step to understand the functional roles of clock genes across different cancer types.” https://lnkd.in/dT2NKaY View in LinkedIn