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DOWNSTREAM EFFECTS. “Melatonin has been linked to regulation of oxidative stress mostly in the mitochondria, where melatonin is reported to stimulate the activity of glutathione peroxidase (GPx) and glutathione reductase (GRd), two enzymes involved in regulation of the glutathione:glutathione disulfide ratio.” https://www.nature.com/articles/s41591-018-0271-8?fbclid=IwAR01C2Z4J5lxVYDLhxIb9dPb3fhNSZSxwimZvhHaJ4n3-nVPpkt2PNqoukk View in LinkedIn

CLOCK HORMONE. “One such link has been made with melatonin, a hormone produced by the pineal gland in a circadian manner to regulate sleep.” https://www.nature.com/articles/s41591-018-0271-8?fbclid=IwAR01C2Z4J5lxVYDLhxIb9dPb3fhNSZSxwimZvhHaJ4n3-nVPpkt2PNqoukk View in LinkedIn

ENDOCRINE NETWORKS. “Interestingly, several lines of epidemiological evidence connecting circadian disruption due to shift work with cancer have largely focused on hormone-dependent diseases such as breast and prostate cancer, which raises the possibility that additional clock-controlled endocrine factors may be at play.” https://www.nature.com/articles/s41591-018-0271-8?fbclid=IwAR01C2Z4J5lxVYDLhxIb9dPb3fhNSZSxwimZvhHaJ4n3-nVPpkt2PNqoukk View in LinkedIn

INTERCONNECTED SYSTEMS. “These studies establish an intriguing link between the transcriptional networks of the clock system with HIF1α and potentially suggest that this crosstalk could be involved in the hypoxic response during tumorigenesis.” https://www.nature.com/articles/s41591-018-0271-8?fbclid=IwAR01C2Z4J5lxVYDLhxIb9dPb3fhNSZSxwimZvhHaJ4n3-nVPpkt2PNqoukk View in LinkedIn

FUTURE WORK. “Therefore, further investigation is required to determine the role of nutritional inputs on circadian metabolism and tumorigenesis.” https://www.nature.com/articles/s41591-018-0271-8?fbclid=IwAR01C2Z4J5lxVYDLhxIb9dPb3fhNSZSxwimZvhHaJ4n3-nVPpkt2PNqoukk View in LinkedIn

METABOLIC FACTORS. “Also, metabolomics analyses in human serum, plasma, and skeletal muscle have identified major populations of rhythmic metabolites over the circadian cycle.” https://www.nature.com/articles/s41591-018-0271-8?fbclid=IwAR01C2Z4J5lxVYDLhxIb9dPb3fhNSZSxwimZvhHaJ4n3-nVPpkt2PNqoukk View in LinkedIn

ALTERNATE PATHWAY. “A similar example exists with nitrogen repurposing of ammonia waste that was reported to be recycled into central amino acid metabolism through the enzymatic activity of glutamate dehydrogenase in breast cancer cells.” https://www.nature.com/articles/s41591-018-0271-8?fbclid=IwAR01C2Z4J5lxVYDLhxIb9dPb3fhNSZSxwimZvhHaJ4n3-nVPpkt2PNqoukk View in LinkedIn

CLOCK TRIGGERS. “Studies in mouse models as well as in human subjects have shown the remarkable effect of specific dietary regimes, such as a high-fat diet, as well as that of time-restricted feeding on the circadian clock.” https://www.nature.com/articles/s41591-018-0271-8?fbclid=IwAR01C2Z4J5lxVYDLhxIb9dPb3fhNSZSxwimZvhHaJ4n3-nVPpkt2PNqoukk View in LinkedIn

METABOLIC SWITCHING. “Clinical and laboratory studies have provided evidence that NSCLC exhibits metabolic heterogeneity in fuel utilization and, while glucose oxidation is metabolically imperative, lactate can also be used as a carbon source.” https://www.nature.com/articles/s41591-018-0271-8?fbclid=IwAR01C2Z4J5lxVYDLhxIb9dPb3fhNSZSxwimZvhHaJ4n3-nVPpkt2PNqoukk View in LinkedIn

RECYCLED WASTES. “Importantly, evidence also suggests that tumor-derived waste can be repurposed and subsequently utilized as fuel for tumors.” https://www.nature.com/articles/s41591-018-0271-8?fbclid=IwAR01C2Z4J5lxVYDLhxIb9dPb3fhNSZSxwimZvhHaJ4n3-nVPpkt2PNqoukk View in LinkedIn