Category: Uncategorized

UNKNOWNS. “Further investigation is needed to better understand how the clock controls metastasis in different cancer types and how this tumor-dependent secretome may differ because of disease profile.” https://www.nature.com/articles/s41591-018-0271-8?fbclid=IwAR01C2Z4J5lxVYDLhxIb9dPb3fhNSZSxwimZvhHaJ4n3-nVPpkt2PNqoukk View in LinkedIn

CLOCKS AND CANCER. “These findings suggest a crosstalk between the circadian clock and cancer cells through the tumor-derived macroenvironment and underscore the ability of canonical and noncanonical clock components to regulate a metastatic secretome.” https://www.nature.com/articles/s41591-018-0271-8?fbclid=IwAR01C2Z4J5lxVYDLhxIb9dPb3fhNSZSxwimZvhHaJ4n3-nVPpkt2PNqoukk View in LinkedIn

QUESTION. “Can the circadian clock feedback and regulate properties of tumorigenesis? If so, what are these circadian cues that modulate cancer progression systemically?” https://www.nature.com/articles/s41591-018-0271-8?fbclid=IwAR01C2Z4J5lxVYDLhxIb9dPb3fhNSZSxwimZvhHaJ4n3-nVPpkt2PNqoukk View in LinkedIn

Very early evidence of the use of glasses (Lyon Art Museum). View in LinkedIn

SAND CASTLES. “I consider it quite possible that physics cannot be based on the field concept, i.e. on continuous structures. In that case, nothing remains of my entire castle in the air, gravitation theory included, and of the rest of modern physics." (Einstein). https://lnkd.in/ej5vMhyF View in LinkedIn

TOXIC OXYGEN RADICALS. “Notably, dampened melatonin secretion caused by sleep disruption may increase reactive oxygen species (ROS) levels and reactive nitrogen species (RNS) production, as suggested by studies in night-shift workers.” https://www.nature.com/articles/s41591-018-0271-8?fbclid=IwAR01C2Z4J5lxVYDLhxIb9dPb3fhNSZSxwimZvhHaJ4n3-nVPpkt2PNqoukk View in LinkedIn

MITOCHONDRIAL EFFECTS. “Interestingly, melatonin regulates the mitochondrial respiratory complexes I and IV and thereby modulates ATP production. Therefore, melatonin may antagonize the glycolytic dependency of cancer cell metabolism in a time-dependent manner by targeting mitochondrial function.” https://www.nature.com/articles/s41591-018-0271-8?fbclid=IwAR01C2Z4J5lxVYDLhxIb9dPb3fhNSZSxwimZvhHaJ4n3-nVPpkt2PNqoukk View in LinkedIn

CORRELATION. “The complex network of communication between the circadian clock and tumorigenesis is only beginning to be unraveled (Fig. 3). At the foundation is strong epidemiological evidence that implicates circadian disruption with cancer.” https://www.nature.com/articles/s41591-018-0271-8?fbclid=IwAR01C2Z4J5lxVYDLhxIb9dPb3fhNSZSxwimZvhHaJ4n3-nVPpkt2PNqoukk View in LinkedIn

RX TIMING. “This so-called ‘chronotherapy’ has been recently reviewed in depth, and evidence strongly supports the idea that metabolic and xenobiotic detoxification enzymes exhibit temporal peaks in activity and thus should be pharmacologically targeted based on optimal time of day.” https://www.nature.com/articles/s41591-018-0271-8?fbclid=IwAR01C2Z4J5lxVYDLhxIb9dPb3fhNSZSxwimZvhHaJ4n3-nVPpkt2PNqoukk View in LinkedIn

ANTIMATTER QUARKS. “Their fleeting existence makes the antimatter quarks within protons difficult to study, but their existence is discernible in reactions in which a matter–antimatter quark pair annihilates.” https://www.nature.com/articles/s41586-021-03282-z View in LinkedIn