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"REGENERATIVE MEDICINE is a new and expanding area that aims to replace lost or damaged tissues in the human body through either cellular transplantation or endogenous repair. Adult stem cells infused into the circulation are currently leading the clinical front of regenerative medicine." http://hmg.oxfordjournals.org/content/early/2013/08/19/hmg.ddt379.full View in LinkedIn

NO MORE EMBRYONIC ETHICAL ISSUES. "Clearly, using hiPSCs (iPS) in regenerative medicine removes the hESC-associated (embryonic stem cell) ethical issues that resulted in restricted funding of this research in the USA and other countries. It also raises the possibility of autologous transplantation." http://hmg.oxfordjournals.org/content/early/2013/08/19/hmg.ddt379.full View in LinkedIn

iPS OR iPSC INDUCED PLURIPOTENT CELLS. "Since their discovery in 2006, induced pluripotent stem cells (iPSCs) have promised to revolutionize regenerative medicine and therapies. Similar to embryonic stem cells, iPSCs possess pluripotency but avoid the associated ethical issues." http://lnkd.in/dJbF8sb View in LinkedIn

STEM CELLS MAY BE DERIVED FROM EMBRYOS OR ADULTS. "Since iPSCs can be derived directly from adult tissues, they not only bypass the need for embryos, but can be made in a patient-matched manner ... each individual could have their own pluripotent stem cell line." http://lnkd.in/dMsngrG View in LinkedIn

"IT WAS REVOLUTIONARY when Takahashi and Yamanaka showed in 2006 that adult mouse fibroblasts could also be sent back in time to an embryonic-like state by simply exogenously expressing powerful pluripotency transcription factors." http://hmg.oxfordjournals.org/content/early/2013/08/19/hmg.ddt379.full View in LinkedIn

THE POWER OF INDUCED PLURIPOTENT STEM CELLS "lies in their potential ability to produce any cell in the human body" without using controversial embryonic tissues, and without rejection if autologous cells are used. http://hmg.oxfordjournals.org/content/early/2013/08/19/hmg.ddt379.full View in LinkedIn

WHY ARE iPS CELLS A BIG DEAL? "Cell differentiation was seen as final and irreversible. Once a cell became specialized ... It was considered locked-in and unable to become any other cell type. However, in 2006, scientists reported that they had turned a differentiated cell back into a stem cell with the potential to become any type of cell in the body." http://learn.genetics.utah.edu/content/stemcells/ips/ View in LinkedIn

INDUCED PLURIPOTENT STEM CELLS "are a type of pluripotent stem cell that can be generated directly from adult cells ... pioneered by Shinya Yamanaka’s lab in Kyoto, Japan, (2006) ... the introduction of four specific genes could convert adult cells to pluripotent stem cells. He was awarded the 2012 Nobel Prize along with Sir John Gurdon." http://lnkd.in/dMsngrG View in LinkedIn

META-ANALYSIS OF CORD VS BONE MARROW TRANSPLANTS. "Six studies were included in the review; three included children (n=477) and three included adults (n=1,312)." They concluded that the outcomes were similar but that the statistical and clinical variability made the data unreliable. Despite many thousands of procedures, few big studies on outcomes. http://www.crd.york.ac.uk/crdweb/ShowRecord.asp?LinkFrom=OAI&ID=12007001220 View in LinkedIn

MEDIPOST, KOREA: leading a "new era of mass-manufactured ... stem cell drug products" to treat knee and cartilage defects, neurodegenerative diseases including Alzheimer's (AD) and ALS, pulmonary disorders, and blood diseases. Using non-controversial cells from unrelated umbilical cord cell banks. In phase I trials in ALzheimer's. http://www.medi-post.com/am_1.asp View in LinkedIn