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iPS TO MAKE PLATELETS. "The donor-dependent supply of platelets is frequently insufficient to meet transfusion needs ... we developed a clinically applicable strategy for the derivation of functional platelets from human pluripotent stem cells (PSCs). This approach involves the establishment of stable immortalized megakaryocyte progenitor cell lines." http://lnkd.in/dyhcv7G View in LinkedIn

GROUNDBREAKING FIRST HUMAN iPS TRIAL. "World’s first induced pluripotent stem cells clinical study on humans launches in Japan. Earlier this year doctors announced success in restoring sight to a man suffering from macular degeneration by treating him with stem cells derived from human embryos." http://stemcellstm.alphamedpress.org/site/misc/News159.xhtml View in LinkedIn

HUMAN PLURIPOTENT CELL BANKS. "The mission of the International Stem Cell Registry is to provide a searchable, comprehensive database that includes published and validated unpublished information on human embryonic (hESC) and disease-specific induced pluripotent (iPS) stem cell lines." http://lnkd.in/dNaD3RV View in LinkedIn

POC: STEM CELLS CURE MOUSE EYE DISEASE. "Just last month a team of doctors ... reported how they had taken stem cells from mice embryos, “turned” them into photoreceptors in the lab and then used them to restore sight in adult mice." This is truly the start of space age medicine. http://stemcellstm.alphamedpress.org/site/misc/News159.xhtml View in LinkedIn

NEGLIGIBLE TUMOR FEARS WITH iPS. "Considering the number of rodents used, the monitoring period, the sensitivity of detecting tumors via subcutaneous and subretinal administration routes and the incidence of tumor formation from the iPSC-derived RPE, we conclude that the tumorigenic potential of the iPSC-derived RPE was negligible." http://lnkd.in/dpPjkpG View in LinkedIn

SHORT-LIVED STEM CELLS. "There is general acceptance that mesenchymal cells, cord blood, adipose tissues and other adult stem cell sources often do not survive for more than a few weeks in patients, and their effects are most likely through growth factor release, host inflammatory responses and vascular alterations rather than replacing tissues lost in the disease." http://hmg.oxfordjournals.org/content/early/2013/08/19/hmg.ddt379.full View in LinkedIn

iPS BACKGROUND. "Traditionally, scientists have worked with both embryonic and adult stem cells as research tools ... Although some adult stem cells do have differentiation capacity, it is often limited in nature, which creates narrow options for use. Thus, induced pluripotent stem cells represent a promising combination of adult and embryonic stem cell characteristics." http://www.prnewswire.com/news-releases/complete-2014-induced-pluripotent-stem-cell-ipsc-industry-report-245515681.html View in LinkedIn

iPS IN OTHER DISEASES. "Although cells that release insulin in response to glucose can be produced, they appear very frail ... A similar story is found for human iPSC-derived cardiomyocytes that can definitely beat in the culture dish ... but do not display all of the expected phenotypes of mature cells." http://hmg.oxfordjournals.org/content/early/2013/08/19/hmg.ddt379.full View in LinkedIn

RECENT LANDMARK DISCOVERY. "Groundbreaking experimentation in 2006 led to the introduction of induced pluripotent stem cells (iPSC). These are adult cells which are isolated and then transformed into embryonic-like stem cells ... Kyoto University in Japan was the first instance in which there was successful generation of the iPSC." http://www.prnewswire.com/news-releases/complete-2014-induced-pluripotent-stem-cell-ipsc-industry-report-245515681.html View in LinkedIn

STEM CELL EXPLOSION. "First successful culture of adult stem cells ... took only seven years from that to ... culturing of embryonic stem cells in mice. The "explosion" of stem cell culturing methodologies in the 1990s ... and the first reprogramming of human skin cells to induced pluripotent stem (iPS) cells by Shinya Yamanaka in 2007." http://lnkd.in/dngY7-A View in LinkedIn