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NEXT FRAGMENT FROM NATURE will continue with the theme of the microbiota and the microbiota. This is an important illustration of the depth of our symbiosis with our companion bacteria. It represents a true sea-change in our scientific appreciation of the role of the microbiome in health and disease, and will undoubtedly eventually trickle down to clinical practice. View in LinkedIn

"DOPAMINE is involved in the regulation of feeding"...and is released in the brain in proportion to the pleasure experience while eating. Half of dopamine production is under microbiome control. https://lnkd.in/eJn4dQU View in LinkedIn

SEROTONIN AND STRESS. "The ability of the gut microbiota to control tryptophan metabolism along the kynurenine pathway...the enzymes of this pathway are immune- and stress-responsive." Tryptophan is the starting point for the synthesis of serotonin. https://lnkd.in/eTgJdPy View in LinkedIn

PIEZO 'PUTER. "New polymer-piezoelectric hybrid creates potential for 'materials that compute'. A hybrid material that is fueled by an oscillatory chemical reaction and can perform computations based on changes in the environment or movement, and potentially even respond to human vital signs." https://lnkd.in/egr-WpF View in LinkedIn

SEROTONIN AT THE TASTE BUD. "A large body of evidence suggests that 5-HT is used as a neurotransmitter in the taste bud to modulate cellular responses to tastant stimulation even before transmission to primary affective gustatory neurons." https://lnkd.in/eaetUhy View in LinkedIn

PIEZO HEARING. "In response to mechanical stimuli, piezoelectric materials generate electricity, suggesting that they could be used in place of hair cells to create an artificial cochlear epithelium." https://lnkd.in/eSZn2RU View in LinkedIn

MECHANISM. "5-HT and NA affect taste cell excitability by altering ion channel function. 5-HT modulates response in primary gustatory neurons."Serotonin and noradrenaline MOA. https://lnkd.in/eaetUhy View in LinkedIn

"PIEZOELECTRIC MATERIALS mimic the function of the cochlear sensory epithelium. Cochlear hair cells convert sound vibration into electrical potential, and loss of these cells diminishes auditory function." https://lnkd.in/eSZn2RU View in LinkedIn

DEPRESSION and anxiety also result in diminished appetite. There is considerable evidence that 5-HT and NA are involved in taste regulation at the level of the taste bud. https://lnkd.in/eaetUhy View in LinkedIn

BUG POWER. "The first of its kind to produce electricity by harnessing the piezoelectric properties of a biological material and could lead to devices that harness electrical energy from the vibrations of everyday tasks. By using viruses that convert mechanical energy into electricity." https://lnkd.in/e966GiP View in LinkedIn