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"CENTRIOLES could act as information carriers throughout generations. The discovery raises the possibility that transmission of biological information could involve more than just genes." https://lnkd.in/eGFHEVJ View in LinkedIn

VIRAL CONTRIBUTION. "The bottom line is that many major diseases that have been associated with inflammation—including cardiovascular disease, neurodegeneration, allergic diseases, cancer, and autoimmunity—occur in persons that are chronically infected by viruses." http://www.sciencedirect.com/science/article/pii/S0092867409007831 View in LinkedIn

NEW VIRUSES. "Further viral diseases may be awaiting either the identification of new viruses or the assessment of relationships between individual human genes, the virome, and specific diseases. Thus, the existence of a viral contribution to our metagenome may exact a large price in those of us with specific genetic predispositions to disease." http://www.sciencedirect.com/science/article/pii/S0092867409007831 View in LinkedIn

SLEEPERS. "These new data suggest that we should consider that many or all humans are genetically “immunocompromised” to a greater or lesser extent for specific infections, including infection by viruses that constitute our virome. Thus, a virus present in all of us may cause disease only in those unfortunate enough to have a specific constellation of genes." http://www.sciencedirect.com/science/article/pii/S0092867409007831 View in LinkedIn

PROLIFERATION. "ERVs are transcribed in a variety of normal and diseased tissues, and they can proliferate within the genome over evolutionary time either by production of viruses that reinfect the genome or by retrotransposition." http://www.sciencedirect.com/science/article/pii/S0092867409007831 View in LinkedIn

PROTEIN EXPRESSION. "Some ERVs are replication competent, but many are replication defective. And yet even such defective ERVs can express proteins. Human ERVs from over 30 lineages constitute perhaps 8%–9% of the human genome." http://www.sciencedirect.com/science/article/pii/S0092867409007831 View in LinkedIn

GENERATING NEW INFORMATION. "The mutation rate of HIV...could evolve a 4 bit site in 100 generations, ~9 months, but it could be much faster because the enormous titer [10(10) new virions/day/person] provides a larger pool for successful changes." https://lnkd.in/eqY6kcy View in LinkedIn

"BIOLOGICAL INFORMATION, measured in the strict Shannon sense, can rapidly appear in genetic control systems subjected to replication, mutation and selection." https://lnkd.in/eqY6kcy View in LinkedIn

HUMAN SPLICE ACCEPTOR SITES. Information in the nucleotide binding sites: "human splice acceptor sites contain ~9.4 bits of information on average." https://lnkd.in/e8egMih View in LinkedIn

SIMULATED EVOLUTION. "The simulation begins with zero information and, as in naturally occurring genetic systems, the information measured in the fully evolved binding sites is close to that needed to locate the sites in the genome. The transition is rapid, demonstrating that information gain can occur by punctuated equilibrium." https://lnkd.in/eqY6kcy View in LinkedIn