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HORIZONTAL GENE TRANSFER. "Accumulating evidence has demonstrated that miRNAs, once thought to be unstable molecules, are stable and can be horizontally transferred across species and kingdoms." Bingo. https://lnkd.in/ejyM8yt View in LinkedIn

STABILITY. "While naked microRNAs are highly unstable and are quickly degraded by omnipresent RNases several papers note that circulating microRNAs in blood and various body fluids are highly stable which predisposes them as a potential biomarker for malignant and non-malignant diseases." https://lnkd.in/erkHGt5 View in LinkedIn

STABLE IN BODY FLUIDS. "Recent studies by our group and others have shown that microRNAs (miRNAs), a class of 19–24 nucleotide-long non-coding RNAs acting as post-transcriptional regulators of gene expression in eukaryotes, can circulate in the bloodstream and other bodily fluids in a stable, cell-free form." https://lnkd.in/ejyM8yt View in LinkedIn

FASCINATING TWIST. "Since many microRNA genes are located in the non-protein coding “dark matter” of the genome, a novel function of this “dark matter” is raised regarding interindividual and cross-species epigenetic communication via information transfer by gene products coded by the non-protein coding part of the genome." Worth re-reading. View in LinkedIn

NONCODING DNA BY THE NUMBERS. "In prokaryotes, 5–25% of the total DNA is nonprotein coding, whereas the non-protein-coding DNA of eukaryotes increases from 50% in simple eukaryotes to 75% in plants and invertebrates and to 85–95% in higher vertebrates." https://lnkd.in/e7k83PD View in LinkedIn

WIDE EPIGENETIC CONTROL. "Supposing that microRNAs might traverse the gastrointestinal tract, microRNAs might wander via the food-chain and even master regulatory microRNAs might be envisaged that could influence gene expression in a wide range of species and might thereby link different species via common gene expression signatures." https://lnkd.in/eDgvwR4 View in LinkedIn

MiRNAs INCREASE WITH COMPLEXITY. "The proportion of non-protein-coding DNA involved in regulation of protein synthesis increases with developmental complexity, whereas the number and repertoire of protein-coding genes remain relatively static." https://lnkd.in/e7k83PD View in LinkedIn

THERAPEUTIC POTENTIAL. "Recently, miRNA-mediated cross-kingdom communication has become an interesting but controversial topic since it was first reported in 2011. These findings provide new insights for genetic regulation by food ingestion and raise the prospect of engineering food or using oral small nucleic acid to prevent or cure diseases." What is the basis for herbal medicines? https://lnkd.in/ecyjYr4 View in LinkedIn

IMPORTANT NONCODING RNAs. "MicroRNAs (miRNAs) are one of a growing class of noncoding RNAs that are involved in the regulation of a wide range of metabolic processes including cellular differentiation, cell proliferation and apoptosis. Clinically, miRNAs are becoming increasingly important following the recognition that some congenital abnormalities can be traced to defects in miRNA processing." https://lnkd.in/e7k83PD View in LinkedIn

HOMOLOGOUS FUNCTIONALITY. "A high degree of parallelism is found in the molecular basis of miRNA biogenesis and action in plants and animals. Recent studies interestingly suggest a potential cross-kingdom action of plant-derived miRNAs, through dietary intake, in regulating mammalian gene expression...the source and scope of plant miRNAs detected in mammalian specimens remain controversial." https://lnkd.in/e_qsx9z View in LinkedIn