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MiRNAs INCREASE WITH COMPLEXITY. "The proportion of non-protein-coding DNA involved in regulation of protein synthesis increases with developmental complexity, whereas the number and repertoire of protein-coding genes remain relatively static." https://lnkd.in/e7k83PD View in LinkedIn

THERAPEUTIC POTENTIAL. "Recently, miRNA-mediated cross-kingdom communication has become an interesting but controversial topic since it was first reported in 2011. These findings provide new insights for genetic regulation by food ingestion and raise the prospect of engineering food or using oral small nucleic acid to prevent or cure diseases." What is the basis for herbal medicines? https://lnkd.in/ecyjYr4 View in LinkedIn

IMPORTANT NONCODING RNAs. "MicroRNAs (miRNAs) are one of a growing class of noncoding RNAs that are involved in the regulation of a wide range of metabolic processes including cellular differentiation, cell proliferation and apoptosis. Clinically, miRNAs are becoming increasingly important following the recognition that some congenital abnormalities can be traced to defects in miRNA processing." https://lnkd.in/e7k83PD View in LinkedIn

HOMOLOGOUS FUNCTIONALITY. "A high degree of parallelism is found in the molecular basis of miRNA biogenesis and action in plants and animals. Recent studies interestingly suggest a potential cross-kingdom action of plant-derived miRNAs, through dietary intake, in regulating mammalian gene expression...the source and scope of plant miRNAs detected in mammalian specimens remain controversial." https://lnkd.in/e_qsx9z View in LinkedIn

REGULATORY ROLE. "It has become increasingly evident that microRNAs are involved in the regulation of a large number of cellular processes. MicroRNAs are found in all human cells and currently almost 2000 sequences are listed in the microRNA database." https://lnkd.in/erkHGt5 View in LinkedIn

HOT QUESTION. "Could plant miRNAs be regulating gene expression within the consumer?" https://lnkd.in/eci-H_v View in LinkedIn

CROSS-KINGDOM REGULATION. "Since a plant miRNA (miR168) cross-regulating a mammalian transcript was reported, miRNA-mediated cross-kingdom communication has become one of the most compelling but controversial topics." https://lnkd.in/ecyjYr4 View in LinkedIn

MICRO-RNAS IN FOOD. "microRNAs have been extensively discovered in various dietary resources including plants (e.g. rice and tomato) and animals (e.g. milk and meats). Given the broad implications of microRNA in health and disease, research enthusiasm for functional impacts of exogenous food microRNA in human cellular phenotypes has soared." https://lnkd.in/ej7XF-E View in LinkedIn

EXTRACELLULAR POPULATION. "According to current knowledge, extracellular miRNAs may be actively secreted by donor cells via membranous vesicles, or just merely by-products of cell death and released passively into the outer space after the cell membranes lose integrity." https://lnkd.in/ejyM8yt View in LinkedIn

MASSIVE EFFECTORS. "In animal cells, miRNAs inhibit translation or stability of mRNA transcripts by binding to them with largely imperfect complementarity. By recognition of hundreds of mRNA transcripts, a single miRNA can shift the entire transcription profile of a cell, consistent with a pivotal role for miRNAs in establishing and maintaining tissue identity." https://lnkd.in/eci-H_v View in LinkedIn