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miRNA AND NEURODEGENERATION. "Dysregulation of microRNA-219 promotes neurodegeneration through post-transcriptional regulation of tau." https://lnkd.in/esYAtUn View in LinkedIn

miRNA AS MARKERS. "The differential expression and responses of selected c-miRNAs in overweight/obese individuals to an exercise and diet intervention suggests a putative role for these ‘biomarkers’ in the prediction or detection of individual variability to weight loss interventions." https://lnkd.in/eSJwPqc View in LinkedIn

DIET AND HEALTH. "Many people carefully monitor their food choices, adhering to the philosophy that ‘you are what you eat’. Recent research adds a new wrinkle to that old adage, suggesting that dietary small RNAs (sRNAs) can control the gene expression of the consumer and may provide an effective, noninvasive, and inexpensive therapy for many human diseases." http://www.sciencedirect.com/science/article/pii/S0167779915001250 View in LinkedIn

DIET AND DISEASE. "Based on these evidences, challenging questions may be raised regarding how humans pick up microRNAs from diet and what are the broader roles played by such exogenous microRNAs in human disease processes." https://lnkd.in/ej7XF-E View in LinkedIn

SO ENDS the fragment on evolutionary convergence. The dual mechanisms of selective pressures and genetic variation, combined with millions of generations over time, constitute an incomparable bio-innovation machine, as evidenced by the endless examples of convergence in nature. With simultaneous solution of major niche problems by different species also comes a fountain of biological diversity. Next weekend, evolutionary simplification. View in LinkedIn

RARE CONVERGENCE. "It is clear that the vast majority of sequences in the genomes have domain architectures which have arisen by evolutionary descent rather than due to functional necessity. In short, convergent evolution of domain architectures is rare...we conclude that between 0.4 and 4% of sequences are involved in convergent evolution of domain architectures, and expect the actual number to be close to the lower bound." http://bioinformatics.oxfordjournals.org/content/21/8/1464.full View in LinkedIn

MINIMAL UNIT OF EVOLUTION. "A domain is the smallest unit of evolution by the definition from the SCOP database of known protein structures. Small proteins consist of a single domain, and some larger proteins consist of more than one domain. A part of a protein is only considered a domain in its own right if it is observed elsewhere in nature on its own or in combination with different partner domains." https://lnkd.in/efF6yTb View in LinkedIn

RARE POINT MUTATION EFFECTS. "Phenotypic convergence has indeed been connected to identical replacements of single amino acids within the encoded product of a protein-coding gene occurring independently in unrelated taxa; however, such examples are rare." https://lnkd.in/eBMUXjN View in LinkedIn

LYSOZYME. "We reanalyzed the stomach lysozyme sequences of foregut fermenters and found that parallel evolution is statistically significant, whereas convergent evolution is not well supported." http://mbe.oxfordjournals.org/content/14/5/527.short View in LinkedIn

HOMOLOGS. "Detection of Convergent and Parallel Evolution at the Amino Acid Sequence Level. Adaptive evolution at the molecular level can be studied by detecting convergent and parallel evolution at the amino acid sequence level. For a set of homologous protein sequences, the ancestral amino acids at all interior nodes of the phylogenetic tree of the proteins can be statistically inferred." https://lnkd.in/eeQXHPj View in LinkedIn