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DNA PACKAGING into chromosomes, the next step. Another brilliant animation. https://lnkd.in/efNVEqJ View in LinkedIn

CYCLE ORDERLINESS. "Because the cell division is conducted in an orderly manner, the progression of the cell cycle is highly coordinated. Premature entry of a cell into the next cell cycle phase would result in significant propensity for genomic alterations. Cell cycle checkpoints are built to ensure that progression from one phase to the next is under a condition of minimum risk of genomic alteration." http://www.sciencedirect.com/science/article/pii/S1535610803000278 View in LinkedIn

DNA REPLICATION ANIMATION. Complexity reduced to beauty. A picture animation is worth a thousand words. A must-see. Show your children. https://lnkd.in/ez8JfGr View in LinkedIn

THE GATEKEEPERS. "The majority of DNA synthesis performed in a human cell is replication of the six billion nucleotide nuclear genome. The bulk of this polymerization is likely to be catalyzed by DNA polymerases δ, DNA polymerase ε, or both." https://lnkd.in/euw7dRD View in LinkedIn

TWO LIFE STRATEGIES. "We have extensive mechanisms to proof-read our DNA and keep out errors. Viruses skip this and accumulate errors at a high rate. Some viral errors mean that they cannot complete their life cycle. These are called defective viruses." https://lnkd.in/eV3d7kz View in LinkedIn

CONSTANT INSTABILITY THREATS. "Throughout the cell cycle, the genome encounters various forms of spontaneous and induced DNA damages." https://lnkd.in/bam9PGn View in LinkedIn

HIGH FIDELITY VS DIVERSITY. Two opposing pressures in nature are, on the one hand, the need for high fidelity replication of the DNA in multicellular animals with slow reproductive rates. On the other hand is the profound drive in rapidly reproducing viruses for instance, for enormous genetic diversity and mutation to rapidly adapt to new niches. View in LinkedIn

MITOSIS. "Once the DNA and chromosomes are duplicated in S-phase, the next critical phase in cell division susceptible to genomic instability is mitosis. During mitosis, the sister chromatids are equally distributed in the daughter cells." https://lnkd.in/bam9PGn View in LinkedIn

SINGULAR EVENT. "In the S-phase, the entire genomic DNA is accurately duplicated once and only once per cell cycle. Any tendency for errors in this process would constitute genomic instability." https://lnkd.in/bam9PGn View in LinkedIn

NEXTGEN. "The ultimate goal of cell division for most non-cancerous somatic cells is to accurately duplicate the genome and then evenly divide the duplicated genome into the two daughter cells. This ensures that the daughter cells will have exactly the same genetic material as their parent cell." https://lnkd.in/bam9PGn View in LinkedIn