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AUTO-SCRIPTING CELLS. "Cells write their own genome modifications. Now that we know about the regulated molecular processes that proofread, repair and modify genomic DNA, we can discuss the physiology of how cells protect the genome and write new genomic structures when appropriately stimulated." http://onlinelibrary.wiley.com/doi/10.1113/jphysiol.2014.271130/full View in LinkedIn

FRAGMENT FROM NATURE continues from last weekend with a consideration of global DNA or total global genetic information. A gene is the software that code for proteins that does the work of running the cell. Gene innovations are amplified in proteins due to cooperative effects. Using proteins as a proxy for biodiversity follows the same logic of using DNA as a surrogate marker. Our protein universe reflects the accumulated and amplified genetic information on this planet. View in LinkedIn

READ-WRITE GENOME. "Discoveries in cytogenetics, molecular biology, and genomics have revealed that genome change is an active cell-mediated physiological process. This is distinctly at variance with the pre-DNA assumption that genetic changes arise accidentally and sporadically. The discovery that DNA changes arise as the result of regulated cell biochemistry means that the genome is best modelled as a read–write (RW) data storage system rather than a read-only memory (ROM)." http://onlinelibrary.wiley.com/doi/10.1113/jphysiol.2014.271130/full View in LinkedIn

"PROOFREADING is the primary guardian of DNA polymerase fidelity. New work has revealed that polymerases with intrinsic proofreading activity may cooperate with non-proofreading polymerases to ensure faithful DNA replication." https://lnkd.in/ecNyeKK View in LinkedIn

GENOME PROOFREADING REVIEW. This valuable and in-depth review covers the key points of genetic proofreading. https://lnkd.in/evDtEyU View in LinkedIn

POLYMERASE PROOFREADING. A fabulous animation. Show your kids. https://lnkd.in/eknx3VA View in LinkedIn

NEW VIEWPOINT. "Our appreciation of the DNA transactions that replicate and maintain a stable human genome is changing rapidly due to recent discoveries indicating that eukaryotic cells contain many more DNA polymerases than previously thought.' http://www.sciencedirect.com/science/article/pii/S1535610803000278 View in LinkedIn

POLYMERASE TYPES. "DNA polymerases are enzymes that synthesize DNA. These proteins have an essential role in genome duplication, but they are also critical for protecting the cell against the effects of DNA damage. There are fifteen different DNA polymerases encoded in mammalian genomes, which are specialized for replication, repair or the tolerance of DNA damage. New evidence is emerging for lesion-specific and tissue-specific functions of DNA polymerases." https://lnkd.in/e_FVkkp View in LinkedIn

MUTATOR DNA POLYMERASES. "Adaptive point mutation and amplification are induced responses to environmental stress, promoting genetic changes that can enhance survival." (E. Coli). https://lnkd.in/eJ456JB View in LinkedIn

MOST ABUNDANT. "Another contender for the title of most abundant protein is ACP, the Acyl carrier protein, which plays an important role in fatty acid biosynthesis. This protein carries fatty acid chains as the chains are elongated. It is claimed to be the most abundant protein in E. coli, with about 60,000 molecules per cell. In a recent high throughput mass spectrometry measurement on minimal medium, a value of ≈80,000 was reported making it the third most abundant protein reported." https://lnkd.in/e9f92vG View in LinkedIn