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50,000 INTERACTIONS. "This number is much higher if one considers the many possible combinations of interactions any protein may make at different times, or if one includes interactions between proteins and other macromolecules (e.g., DNA and RNA). A major challenge in cell biology is thus to elucidate dynamic interactomes of consequence and to understand how these interactomes lead to cellular phenotypes." https://lnkd.in/eVepjNC View in LinkedIn

VAST PROTEIN INTERACTIONS. "Proteins are the central players in interactomes. Most eukaryotic cells express several thousand proteins, and multicellular organisms commonly express tens of thousands of proteins, exponentially increasing the probable total number of macromolecular interactions in these organisms, all passing information on pathways linking each other throughout the cell. For example, analyses suggest on the order of 50,000 different protein interaction pairs, and perhaps four times more in humans." https://lnkd.in/eVepjNC View in LinkedIn

COMMUNITY OF ASSOCIATIONS. "There is no single, fixed human interactome. Instead, it is likely that the number of interaction networks might number in the thousands, perhaps even an infinite number. There is no single human interactome. There are many. " https://genomebiology.biomedcentral.com/articles/10.1186/s13059-016-0913-4 View in LinkedIn

INTERACTING MODULES. "If two disease modules overlap, local perturbations causing one disease can disrupt pathways of the other disease module as well, resulting in shared clinical and pathobiological characteristics." http://science.sciencemag.org/content/347/6224/1257601 View in LinkedIn

COMMUNITY OF LIVING MACHINES. "The properties of living cells are mediated by a huge number of ever-changing interactions of their component macromolecules forming living machines; collectively, these are termed the interactome. Pathogenic alterations in interactomes mechanistically underlie diseases." https://lnkd.in/eVepjNC View in LinkedIn

BEYOND VIEW. "These findings indicate that many local neighborhoods of the interactome represent the observable part of the true, larger and denser disease modules." http://science.sciencemag.org/content/347/6224/1257601 View in LinkedIn

GIANT TASK. "Even considering only one splice variant per gene, approximately 20,000 protein-coding genes must be handled and ∼200 million protein pairs tested to generate a comprehensive binary reference PPI map. Even with nearly complete, high-quality reference interactome maps of biophysical interactions, how can the biological relevance of each interaction be evaluated under physiological conditions?" (PPI = Protein-Protein Interactions). http://www.sciencedirect.com/science/article/pii/S0092867414014226 View in LinkedIn

DISEASE MODULES. "We find that disease proteins associated with 226 diseases are clustered in the same network neighborhood, displaying a statistically significant tendency to form identifiable disease modules. The higher the degree of agglomeration of the disease proteins within the interactome, the higher the biological and functional similarity of the corresponding genes." http://science.sciencemag.org/content/347/6224/1257601 View in LinkedIn

GENOME-PHENOTYPE LINKS. "Even when identified, it is often unclear how a causal mutation perturbs the function of the corresponding gene or gene product. To “connect the dots” of the genomic revolution, functions and context must be assigned to large numbers of genotypic changes." http://www.sciencedirect.com/science/article/pii/S0092867414014226 View in LinkedIn

DISEASE CLUSTER. "The documented propensity of disease-associated proteins to interact with each other suggests that they tend to cluster in the same neighborhood of the interactome, forming a disease module, a connected subgraph that contains all molecular determinants of a disease." http://science.sciencemag.org/content/347/6224/1257601 View in LinkedIn