Category: Uncategorized

MANY HUMAN INTERACTOMES. "How they are different and regulated is crucial for their understanding. Protein interaction networks are dynamic and context dependent. The differences in networks between cellular states are probably determined by key regulatory mechanisms for controlling these states." https://genomebiology.biomedcentral.com/articles/10.1186/s13059-016-0913-4 View in LinkedIn

PART OF THE WHOLE. "The function of a protein is often tied to its interactions, and many proteins function as components of large multiprotein complexes. Multiprotein complexes also will connect to each other in a cell to carry out coordinated biological functions. Every cell has a network of protein interactions, where these connections within and between proteins and complexes yield insights into cellular states." https://genomebiology.biomedcentral.com/articles/10.1186/s13059-016-0913-4 View in LinkedIn

COLLABORATIVE GROUPS. "As proteins form larger assemblies to confer context-specific functionality, the systematic analysis of protein–protein interactions (PPIs) is a powerful strategy for identifying physiological pathways associated with a protein of interest, following the “guilt of association” principle, and to further characterize these pathways by unveiling the physical contacts that underlie them." https://lnkd.in/eA-DhWV View in LinkedIn

VISUAL DESCRIPTION of the protein-protein interactome complexity. https://lnkd.in/eA-DhWV View in LinkedIn

CONSERVED PATTERNS. "The networks of protein–protein interactions, or interactomes, although distinctive to their individual organisms, manifest global and local characteristics that are shared across species. Most notably, the organization of these networks exhibits a scale-free topology with a substantial number of highly connected hub proteins." https://lnkd.in/eTyvTV7 View in LinkedIn

82 MILLION PROTEIN PAIRS. "To identify these interactions, the researchers used a high-throughput yeast two-hybrid approach, in which 82 million protein pairs were each tested four times in two different configurations for their ability to activate a reporter gene in yeast." https://lnkd.in/etGh98E View in LinkedIn

50,000 INTERACTIONS. "This number is much higher if one considers the many possible combinations of interactions any protein may make at different times, or if one includes interactions between proteins and other macromolecules (e.g., DNA and RNA). A major challenge in cell biology is thus to elucidate dynamic interactomes of consequence and to understand how these interactomes lead to cellular phenotypes." https://lnkd.in/eVepjNC View in LinkedIn

VAST PROTEIN INTERACTIONS. "Proteins are the central players in interactomes. Most eukaryotic cells express several thousand proteins, and multicellular organisms commonly express tens of thousands of proteins, exponentially increasing the probable total number of macromolecular interactions in these organisms, all passing information on pathways linking each other throughout the cell. For example, analyses suggest on the order of 50,000 different protein interaction pairs, and perhaps four times more in humans." https://lnkd.in/eVepjNC View in LinkedIn

COMMUNITY OF ASSOCIATIONS. "There is no single, fixed human interactome. Instead, it is likely that the number of interaction networks might number in the thousands, perhaps even an infinite number. There is no single human interactome. There are many. " https://genomebiology.biomedcentral.com/articles/10.1186/s13059-016-0913-4 View in LinkedIn

NETWORK MODULE. "The network is tightly connected, with the edges typically linking the nodes through multiple genes. Clearly, this network is a module of a much large network that connects most of the virus world." http://virologyj.biomedcentral.com/articles/10.1186/1743-422X-10-158 View in LinkedIn