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ACTIVE GENOME EDITING AGENTS. "The reductionistic and mechanistic views on physico-chemical properties of the genetic code are no longer convincing as appropriate descriptions of the abundance of non-random genetic content operators which are active in natural genetic engineering and natural genome editing." https://lnkd.in/eg6uePF View in LinkedIn

USELESS WITHOUT AGENTS. "Genes do nothing on their own...if I take a gene and put it in a Petri dish with as many nutrients as you wish for 10,000 years, it will do absolutely nothing." (Professor Nobel on his book, the Music of Life). https://www.dpag.ox.ac.uk/team/denis-noble View in LinkedIn

ERROR VERSUS INTENTIONALITY. "The abundance of empirical data concerning non-random genetic change operators such as the variety of mobile genetic elements, persistent viruses and defectives do not fit with the dominant narrative of error replication events (mutations) as being the main driving forces creating genetic novelty and diversity." https://lnkd.in/eg6uePF View in LinkedIn

TWO WAY. "The same genome can give rise to very different phenotypes...transmission of information is not just one way...Lamarkism is not so obviously false." (Professor Nobel on his book, the Music of Life). https://www.dpag.ox.ac.uk/team/denis-noble View in LinkedIn

RISE OF RNA AGENTS. "Since Barbara McClintock’s far-reaching detection of mobile genetic elements, the RNA world hypothesis followed by the rise of RNA biology and the comeback of virology, we have a variety of terms for RNA agents that play essential roles in natural genetic engineering and natural genome editing." https://lnkd.in/eg6uePF View in LinkedIn

NEW INFO #2. "The central dogma of molecular biology “DNA-RNA-Protein everything else,” is obsolete nowadays; the reverse direction is also in common use." https://lnkd.in/eUYvi8e View in LinkedIn

RNA WORLD HYPOTHESIS. "The concepts of the origin of the genetic code and the definitions of life changed dramatically after the RNA world hypothesis. Main narratives in molecular biology and genetics such as the “central dogma,” “one gene one protein” and “non-coding DNA is junk” were falsified meanwhile. RNA moved from the transition intermediate molecule into centre stage." An important paper. https://lnkd.in/eg6uePF View in LinkedIn

MAJORITY OF HUMAN GENOME. "Mobile elements form the majority of the human genome, but that is unimportant compared to all of the functional effects these “parasites” have had on our evolution." https://lnkd.in/eYwTvvK View in LinkedIn

MOBILE ELEMENTS. "Coding sequences of functioning human genes derived entirely from mobile element sequences. There are many examples where the synthetic coding sequences of observed mRNA sequences are made up of mobile element sequences, to an extent of 80% or more of the length of the coding sequences." https://lnkd.in/eYwTvvK View in LinkedIn

HALF THE HUMAN GENOME. "Five retroelement families, L1 and L2 (long interspersed nuclear element, LINE), Alu and MIR (short interspersed nuclear element, SINE), and LTR (long terminal repeat), comprise almost half of the human genome." Viral elements. https://lnkd.in/eW9wPwx View in LinkedIn