BURN-OUT IS REAL IN STARTUPS, and the consequences can be truly devastating. A very driven individual risks severe overwork, that results in chronic exhaustion, sleep disturbance, irritability, poor judgement, illness, nervous breakdowns, and depression. Early signs include lack of humor, a short temper, and unrealistic expectations. In the worst cases, this can destroy a business, as well as relationships. It is critical for mentors, colleagues, and board members to watch for symptoms and step in to break the cycle before it gets out of control.