DRUG DEVELOPERS SHOULD KILL MOLECULES. I once knew an entrepreneur who was very smart and developed an important synthetic enzyme. This enzyme was in the oxidative stress pathway, and animal model after animal model yielded positive data. He was passionate about the molecule and grew irrationally attached to it. Even as the IP was fading, and all attempts to fund it had failed, he still could not do what drug developers have to do every day: kill the molecule. Beware the zealot who falls in love with his own work.