FLEMING’S PREDICTION PROVEN. “Penicillin-resistant staph emerged in 1940, while the drug was still being given to only a few patients. Tetracycline was introduced in 1950, and tetracycline-resistant Shigella emerged in 1959; erythromycin came on the market in 1953, and erythromycin-resistant strep appeared in 1968.”
https://medium.com/@fernnews/imagining-the-post-antibiotics-future-892b57499e77