TOXINEERING. “The researchers identified a tarantula spider peptide, protoxin-I, as the first high-affinity peptide antagonist of the transient receptor potential ankyrin 1 (TRPA1) channel. Nitabach’s team also used toxineering to create a novel protoxin-I mutant with improved specificity for TRPA1, underscoring the value of the approach for pharmaceutical discovery.”
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