STRUCTURE-FUNCTION CAUSALITY. “The Mitochondrial Permeability Transition (MPT) pore. The mitochondrial permeability transition pore plays a key role in heart disease. F-ATP synthase is the best molecular candidate for pore formation. Cyclophilin D is an important pore regulator but not a structural component. Cyclophilin inhibitors are promising but promiscuous drugs.”
https://lnkd.in/e5HJzaA
linkedin post 2022-06-29 05:12:48
Nigel Fleming
September 21, 2022