HELPER VIRUS. “DI viruses are defective because the deleted genome lacks an essential gene required for replication. In order to replicate, DI viruses require assistance of the infectious virus from which they were derived, or a genetically compatible related virus, to provide the missing gene products. This is referred to as a helper virus. DI virus production is optimal in the presence of a large amount of helper virus but as the DI virus replicates it reduces the yield of infectious helper virus.”
https://lnkd.in/egCZeY2
linkedin post 2022-06-29 05:12:48
Nigel Fleming
September 21, 2022