CHRONIC INFLAMMATION. “Patterns of local immune activation due to temporary loss of barrier function, pathogen invasion, or release of endogenous mediators, followed by tissue destruction and functional impairment characterize many chronic human disease conditions. The cellular and molecular profiles of immune activation in chronic inflammatory disorders overlap considerably with those patterns observed in effective, self-limited host responses to microbial pathogens and involve similar initiating mechanisms.”
http://www.sciencedirect.com/science/article/pii/S0092867406001917