INFECTION AND CHRONIC DISEASE. “Clinical and epidemiologic studies have suggested an association between infectious agents and chronic inflammatory disorders and cancer. We propose that a key aspect of pathogenesis is an aberrant epithelial barrier that can be instigated by microbial toxins, environmental insults, or the genetic predisposition of the host.”
http://www.sciencedirect.com/science/article/pii/S0092867406001917