GIANT TASK. “Even considering only one splice variant per gene, approximately 20,000 protein-coding genes must be handled and ∼200 million protein pairs tested to generate a comprehensive binary reference PPI map. Even with nearly complete, high-quality reference interactome maps of biophysical interactions, how can the biological relevance of each interaction be evaluated under physiological conditions?” (PPI = Protein-Protein Interactions).
http://www.sciencedirect.com/science/article/pii/S0092867414014226