IMMUNE INNOVATION. “CRISPR-Cas9 deletion of a subset of these ERV elements in the human genome impaired expression of adjacent IFN-induced genes and revealed their involvement in the regulation of essential immune functions, including activation of the AIM2 inflammasome. Although these regulatory sequences likely arose in ancient viruses, they now constitute a dynamic reservoir of IFN-inducible enhancers fueling genetic innovation in mammalian immune defenses.”(ERVs = endogenous retroviruses; IFN = interferon).
https://lnkd.in/dn8M8m8
linkedin post 2022-06-29 05:12:48
Nigel Fleming
September 21, 2022